Andrew M. Demchuk

Research interests

Publications

• Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

  The Lancet · 2022 · 10.1016/s0140-6736(22)01054-6

• Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

  The Lancet · 2020 · https://doi.org/10.1016/s0140-6736(20)30258-0

• Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial

  The Lancet · 2019 · https://doi.org/10.1016/s0140-6736(19)30038-8

• Standards for Detecting, Interpreting, and Reporting Noncontrast Computed Tomographic Markers of Intracerebral Hemorrhage Expansion

  Annals of Neurology · 2019 · https://doi.org/10.1002/ana.25563

• Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors

  New England Journal of Medicine · 2019 · https://doi.org/10.1056/nejmoa1814051

• Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial

  The Lancet · 2019 · https://doi.org/10.1016/s0140-6736(19)30038-8

• Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data

  The Lancet Neurology · 2018 · https://doi.org/10.1016/s1474-4422(18)30253-9

• Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

  New England Journal of Medicine · 2018 · https://doi.org/10.1056/nejmoa1713973

• Intracerebral haemorrhage: current approaches to acute management

  The Lancet · 2018 · 10.1016/s0140-6736(18)31878-6

• Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data

  The Lancet Neurology · 2018 · https://doi.org/10.1016/s1474-4422(18)30242-4

• Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

  The Lancet Neurology · 2017 · https://doi.org/10.1016/s1474-4422(17)30407-6

• Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis

  JAMA · 2016 · https://doi.org/10.1001/jama.2016.13647

• Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke

  New England Journal of Medicine · 2016 · 10.1056/nejmoa1515510

• Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials

  The Lancet · 2016 · https://doi.org/10.1016/s0140-6736(16)00163-x

• Multiphase CT Angiography: A New Tool for the Imaging Triage of Patients with Acute Ischemic Stroke

  Radiology · 2015 · 10.1148/radiol.15142256

• The Heidelberg Bleeding Classification

  Stroke · 2015 · 10.1161/strokeaha.115.010049

• Atrial Premature Beats Predict Atrial Fibrillation in Cryptogenic Stroke

  Stroke · 2015 · https://doi.org/10.1161/strokeaha.115.008714

• Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke

  Stroke · 2015 · 10.1161/str.0000000000000086

• Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke

  New England Journal of Medicine · 2013 · 10.1056/nejmoa1214300

• Recommendations on Angiographic Revascularization Grading Standards for Acute Ischemic Stroke

  Stroke · 2013 · 10.1161/strokeaha.113.001972

• Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study

  The Lancet Neurology · 2012 · 10.1016/s1474-4422(12)70038-8

• Defining hematoma expansion in intracerebral hemorrhage

  Neurology · 2011 · 10.1212/wnl.0b013e3182143317

• Low Rates of Acute Recanalization With Intravenous Recombinant Tissue Plasminogen Activator in Ischemic Stroke

  Stroke · 2010 · 10.1161/strokeaha.110.592535

• CT Angiography Clot Burden Score and Collateral Score: Correlation with Clinical and Radiologic Outcomes in Acute Middle Cerebral Artery Infarct

  American Journal of Neuroradiology · 2009 · 10.3174/ajnr.a1408

• Extent of Hypoattenuation on CT Angiography Source Images Predicts Functional Outcome in Patients With Basilar Artery Occlusion

  Stroke · 2008 · 10.1161/strokeaha.107.511162

• Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial

  The Lancet Neurology · 2007 · 10.1016/s1474-4422(07)70250-8

• Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison

  The Lancet · 2007 · 10.1016/s0140-6736(07)60151-2

• Ultrasound-Enhanced Systemic Thrombolysis for Acute Ischemic Stroke

  New England Journal of Medicine · 2004 · 10.1056/nejmoa041175

• Improving Delivery of Acute Stroke Therapy

  Stroke · 2002 · https://doi.org/10.1161/hs0102.101990

• Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke.

  PubMed · 2001

• Rebleeding leads to poor outcome in ultra-early craniotomy for intracerebral hemorrhage

  Neurology · 2001 · https://doi.org/10.1212/wnl.56.10.1294

• Why are stroke patients excluded from TPA therapy?

  Neurology · 2001 · 10.1212/wnl.56.8.1015

• Effectiveness of t-PA in acute ischemic stroke

  Neurology · 2000 · https://doi.org/10.1212/wnl.54.3.679

• Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy

  The Lancet · 2000 · 10.1016/s0140-6736(00)02237-6

• Serum Glucose Level and Diabetes Predict Tissue Plasminogen Activator–Related Intracerebral Hemorrhage in Acute Ischemic Stroke

  Stroke · 1999 · https://doi.org/10.1161/01.str.30.1.34

Current projects

No projects listed.