Lea T. Grinberg

Research interests

Publications

• Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

  Nature Communications · 2022 · 10.1038/s41467-022-29552-6

• Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study

  The Lancet Neurology · 2021 · https://doi.org/10.1016/s1474-4422(21)00214-3

• Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease

  Nature Neuroscience · 2021 · 10.1038/s41593-020-00764-7

• Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study

  Acta Neuropathologica · 2021 · 10.1007/s00401-020-02255-2

• Comorbid neuropathological diagnoses in early versus late-onset Alzheimer’s disease

  Brain · 2021 · 10.1093/brain/awab099

• Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.10.029

• Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration

  Nature Medicine · 2020 · https://doi.org/10.1038/s41591-020-0762-2

• Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

  Brain · 2019 · 10.1093/brain/awz193

• Multisite study of the relationships between antemortem [ 11 C]PIB‐PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology

  Alzheimer s & Dementia · 2018 · 10.1016/j.jalz.2018.09.001

• Clinicopathological correlations in behavioural variant frontotemporal dementia

  Brain · 2017 · 10.1093/brain/awx254

• Typical and atypical pathology in primary progressive aphasia variants

  Annals of Neurology · 2017 · 10.1002/ana.24885

• ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

  Nature · 2017 · https://doi.org/10.1038/nature24016

• Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early‐stage biomarker discovery

  Alzheimer s & Dementia · 2016 · 10.1016/j.jalz.2016.06.2362

• Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

  Acta Neuropathologica · 2015 · https://doi.org/10.1007/s00401-015-1509-x

• Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

  Proceedings of the National Academy of Sciences · 2015 · 10.1073/pnas.1514475112

• The behavioural/dysexecutive variant of Alzheimer’s disease: clinical, neuroimaging and pathological features

  Brain · 2015 · 10.1093/brain/awv191

• Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation

  Brain · 2015 · 10.1093/brain/awv112

• Primary age-related tauopathy (PART): a common pathology associated with human aging

  Acta Neuropathologica · 2014 · 10.1007/s00401-014-1349-0

• The Brainstem Pathologies of Parkinson's Disease and Dementia with Lewy Bodies

  Brain Pathology · 2014 · 10.1111/bpa.12168

• Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

  Neuron · 2014 · 10.1016/j.neuron.2014.04.047

• Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration

  Annals of Neurology · 2013 · 10.1002/ana.24052

• Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD

  Neurology · 2011 · 10.1212/wnl.0b013e31823b9c5e

• Vascular pathology in the aged human brain

  Acta Neuropathologica · 2010 · 10.1007/s00401-010-0652-7

• Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled‐up primate brain

  The Journal of Comparative Neurology · 2009 · 10.1002/cne.21974

• Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration

  Acta Neuropathologica · 2007 · 10.1007/s00401-007-0237-2

Current projects

No projects listed.