Aimin Xu

Research interests

Publications

• Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

  Cell Death and Disease · 2022 · https://doi.org/10.1038/s41419-022-05034-x

• The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic

  Nature Reviews Endocrinology · 2020 · https://doi.org/10.1038/s41574-020-0386-0

• Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention

  Cell Metabolism · 2019 · https://doi.org/10.1016/j.cmet.2019.11.001

• Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

  Journal of Clinical Investigation · 2019 · https://doi.org/10.1172/jci123069

• CXCL10/CXCR3 signaling mobilized-regulatory T cells promote liver tumor recurrence after transplantation

  Journal of Hepatology · 2016 · https://doi.org/10.1016/j.jhep.2016.05.032

• Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice

  Circulation · 2016 · https://doi.org/10.1161/circulationaha.115.019645

• Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

  Hepatology · 2016 · https://doi.org/10.1002/hep.28523

• Thirty Years of Saying NO

  Circulation Research · 2016 · https://doi.org/10.1161/circresaha.116.306531

• Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice

  Circulation · 2015 · https://doi.org/10.1161/circulationaha.115.015308

• Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation

  Cell Metabolism · 2015 · https://doi.org/10.1016/j.cmet.2015.06.004

• Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin

  Proceedings of the National Academy of Sciences · 2014 · https://doi.org/10.1073/pnas.1415219111

• Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice

  Cell Metabolism · 2013 · https://doi.org/10.1016/j.cmet.2013.04.005

• Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters

  The Pharmacogenomics Journal · 2012 · https://doi.org/10.1038/tpj.2012.43

• Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride

  Journal of Hepatology · 2010 · https://doi.org/10.1016/j.jhep.2010.05.018

• Post-translational modifications of adiponectin: mechanisms and functional implications

  Biochemical Journal · 2008 · https://doi.org/10.1042/bj20071492

• Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans

  Diabetes · 2008 · https://doi.org/10.2337/db07-1476

• Circulating Adipocyte–Fatty Acid Binding Protein Levels Predict the Development of the Metabolic Syndrome

  Circulation · 2007 · https://doi.org/10.1161/circulationaha.106.647503

• Adiponectin-Induced Endothelial Nitric Oxide Synthase Activation and Nitric Oxide Production Are Mediated by APPL1 in Endothelial Cells

  Diabetes · 2007 · 10.2337/db06-1580

• Adiponectin-Induced Endothelial Nitric Oxide Synthase Activation and Nitric Oxide Production Are Mediated by APPL1 in Endothelial Cells

  Diabetes · 2007 · 10.2337/db06-1580

• Adipocyte Fatty Acid–Binding Protein Is a Plasma Biomarker Closely Associated with Obesity and Metabolic Syndrome

  Clinical Chemistry · 2006 · https://doi.org/10.1373/clinchem.2005.062463

• Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice

  Journal of Allergy and Clinical Immunology · 2006 · 10.1016/j.jaci.2006.04.021

• Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice

  Journal of Allergy and Clinical Immunology · 2006 · 10.1016/j.jaci.2006.04.021

• Lipocalin-2 Is an Inflammatory Marker Closely Associated with Obesity, Insulin Resistance, and Hyperglycemia in Humans

  Clinical Chemistry · 2006 · https://doi.org/10.1373/clinchem.2006.075614

• Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes

  Journal of Biological Chemistry · 2005 · https://doi.org/10.1074/jbc.m414231200

• Adiponectin Inhibits Cell Proliferation by Interacting with Several Growth Factors in an Oligomerization-dependent Manner

  Journal of Biological Chemistry · 2005 · https://doi.org/10.1074/jbc.m501149200

• Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice

  Proceedings of the National Academy of Sciences · 2005 · 10.1073/pnas.0408452102

• Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice

  Proceedings of the National Academy of Sciences · 2005 · 10.1073/pnas.0408452102

• Hypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilation

  The Journal of Clinical Endocrinology & Metabolism · 2004 · https://doi.org/10.1210/jc.2003-031012

• The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

  Journal of Clinical Investigation · 2003 · https://doi.org/10.1172/jci200317797

• Hydroxylation and Glycosylation of the Four Conserved Lysine Residues in the Collagenous Domain of Adiponectin

  Journal of Biological Chemistry · 2002 · https://doi.org/10.1074/jbc.m200601200

Current projects

No projects listed.