Wenyi Wei

Research interests

Publications

• Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

  Molecular Cell · 2021 · 10.1016/j.molcel.2021.03.037

• Cancer Selective Target Degradation by Folate-Caged PROTACs

  Journal of the American Chemical Society · 2021 · 10.1021/jacs.1c00451

• Cell cycle on the crossroad of tumorigenesis and cancer therapy

  Trends in Cell Biology · 2021 · 10.1016/j.tcb.2021.07.001

• Light-induced control of protein destruction by opto-PROTAC

  Science Advances · 2020 · 10.1126/sciadv.aay5154

• Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer

  Molecular Cancer · 2020 · 10.1186/s12943-020-01249-8

• Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

  Nature Cell Biology · 2020 · 10.1038/s41556-020-0562-4

• Ubiquitin signaling in cell cycle control and tumorigenesis

  Cell Death and Differentiation · 2020 · 10.1038/s41418-020-00648-0

• The role of ubiquitination in tumorigenesis and targeted drug discovery

  Signal Transduction and Targeted Therapy · 2020 · 10.1038/s41392-020-0107-0

• Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

  Science · 2019 · 10.1126/science.aau0159

• Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

  Nature · 2017 · https://doi.org/10.1038/nature25015

• Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

  Nature Medicine · 2017 · 10.1038/nm.4378

• PtdIns(3,4,5) P 3-Dependent Activation of the mTORC2 Kinase Complex

  Cancer Discovery · 2015 · 10.1158/2159-8290.cd-15-0460

• Targeting Cdc20 as a novel cancer therapeutic strategy

  Pharmacology & Therapeutics · 2015 · 10.1016/j.pharmthera.2015.04.002

• Roles of F-box proteins in cancer

  Nature reviews. Cancer · 2014 · 10.1038/nrc3700

• Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

  Nature · 2014 · 10.1038/nature13079

• Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function

  Cell · 2014 · 10.1016/j.cell.2014.03.027

• The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

  Cell · 2012 · 10.1016/j.cell.2012.02.065

• SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

  Nature · 2011 · 10.1038/nature09732

• Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

  Nature Cell Biology · 2009 · 10.1038/ncb1847

• Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer

  Cancer Cell · 2005 · 10.1016/j.ccr.2005.06.015

• The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

  Cancer Cell · 2005 · 10.1016/j.ccr.2005.06.005

• Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

  Nature · 2004 · 10.1038/nature02381

• Role of p21 in Apoptosis and Senescence of Human Colon Cancer Cells Treated with Camptothecin

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.m112401200

• Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

  Proceedings of the National Academy of Sciences · 1998 · 10.1073/pnas.95.25.14723

• Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

  Science · 1997 · 10.1126/science.277.5327.831

Current projects

No projects listed.