John M. Asara

Research interests

Publications

• Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

  Nature Medicine · 2018 · https://doi.org/10.1038/s41591-018-0019-5

• An inhibitor of oxidative phosphorylation exploits cancer vulnerability

  Nature Medicine · 2018 · https://doi.org/10.1038/s41591-018-0052-4

• MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

  Cancer Cell · 2017 · 10.1016/j.ccell.2017.06.004

• mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

  Science · 2016 · https://doi.org/10.1126/science.aad0489

• Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

  Nature · 2016 · https://doi.org/10.1038/nature19084

• Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

  Science · 2015 · https://doi.org/10.1126/science.aaa5004

• Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

  Molecular Cell · 2015 · https://doi.org/10.1016/j.molcel.2015.05.031

• NRF2 regulates serine biosynthesis in non–small cell lung cancer

  Nature Genetics · 2015 · 10.1038/ng.3421

• Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

  Nature · 2014 · https://doi.org/10.1038/nature13611

• PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

  Nature Cell Biology · 2014 · https://doi.org/10.1038/ncb3039

• AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

  Molecular Cell · 2013 · https://doi.org/10.1016/j.molcel.2013.01.035

• Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

  Nature · 2013 · https://doi.org/10.1038/nature12040

• Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

  Science · 2013 · https://doi.org/10.1126/science.1228792

• Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

  Nature Chemical Biology · 2012 · https://doi.org/10.1038/nchembio.1060

• Influence of Threonine Metabolism on S -Adenosylmethionine and Histone Methylation

  Science · 2012 · 10.1126/science.1226603

• A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

  Nature Protocols · 2012 · https://doi.org/10.1038/nprot.2012.024

• TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

  Molecular Cell · 2012 · 10.1016/j.molcel.2012.06.009

• Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

  Cell · 2012 · 10.1016/j.cell.2012.01.058

• Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

  Nature Genetics · 2011 · https://doi.org/10.1038/ng.890

• SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

  Cell · 2011 · https://doi.org/10.1016/j.cell.2011.10.054

• Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

  Science · 2011 · https://doi.org/10.1126/science.1211485

• Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

  Science · 2010 · 10.1126/science.1188015

• Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

  Science · 2010 · https://doi.org/10.1126/science.1196371

• Pyruvate kinase M2 is a phosphotyrosine-binding protein

  Nature · 2008 · https://doi.org/10.1038/nature06667

• Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation

  Journal of Biological Chemistry · 2003 · https://doi.org/10.1074/jbc.c300063200

• A Method to Identify Serine Kinase Substrates

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.c200198200

• HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

  Science · 2001 · https://doi.org/10.1126/science.1059817

Current projects

No projects listed.