Vikram Deshpande

Research interests

Publications

• A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-13825-8

• Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer

  Cell · 2019 · 10.1016/j.cell.2019.05.012

• Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

  Cell stem cell · 2018 · 10.1016/j.stem.2018.04.001

• Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles

  Cell Reports · 2017 · https://doi.org/10.1016/j.celrep.2017.02.033

• Predictors of Resectability and Survival in Patients With Borderline and Locally Advanced Pancreatic Cancer who Underwent Neoadjuvant Treatment With FOLFIRINOX

  Annals of Surgery · 2017 · https://doi.org/10.1097/sla.0000000000002600

• High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

  Nature · 2016 · https://doi.org/10.1038/nature17173

• Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion–Positive Cholangiocarcinoma

  Cancer Discovery · 2016 · https://doi.org/10.1158/2159-8290.cd-16-1000

• Rituximab for IgG4-related disease: a prospective, open-label trial

  Annals of the Rheumatic Diseases · 2015 · https://doi.org/10.1136/annrheumdis-2014-206605

• IgG4‐Related Disease: Clinical and Laboratory Features in One Hundred Twenty‐Five Patients

  Arthritis & Rheumatology · 2015 · https://doi.org/10.1002/art.39205

• Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

  Nature · 2015 · https://doi.org/10.1038/nature14587

• PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma

  Clinical Cancer Research · 2015 · https://doi.org/10.1158/1078-0432.ccr-15-0715

• Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

  Nature · 2014 · 10.1038/nature13441

• EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma

  Cancer Cell · 2014 · 10.1016/j.ccell.2014.10.004

• Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells

  Cell Reports · 2014 · 10.1016/j.celrep.2014.08.029

• The diagnostic utility of serum IgG4 concentrations in IgG4-related disease

  Annals of the Rheumatic Diseases · 2014 · 10.1136/annrheumdis-2013-204907

• Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4 concentrations

  Annals of the Rheumatic Diseases · 2014 · 10.1136/annrheumdis-2014-205233

• Stromal response to Hedgehog signaling restrains pancreatic cancer progression

  Proceedings of the National Academy of Sciences · 2014 · 10.1073/pnas.1411679111

• Radiological and Surgical Implications of Neoadjuvant Treatment With FOLFIRINOX for Locally Advanced and Borderline Resectable Pancreatic Cancer

  Annals of Surgery · 2014 · https://doi.org/10.1097/sla.0000000000000867

• Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues

  Cell · 2013 · https://doi.org/10.1016/j.cell.2012.12.033

• Pancreatic Ductal Adenocarcinoma

  Annals of Surgery · 2012 · https://doi.org/10.1097/sla.0b013e318263da2f

• Consensus statement on the pathology of IgG4-related disease

  Modern Pathology · 2012 · https://doi.org/10.1038/modpathol.2012.72

• mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

  Nature · 2012 · https://doi.org/10.1038/nature11163

• Recommendations for the nomenclature of IgG4‐related disease and its individual organ system manifestations

  Arthritis & Rheumatism · 2012 · https://doi.org/10.1002/art.34593

• IgG4-Related Disease

  New England Journal of Medicine · 2012 · https://doi.org/10.1056/nejmra1104650

• Rituximab for the Treatment of IgG4-Related Disease

  Medicine · 2011 · 10.1097/md.0b013e3182431ef6

• Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial Cancers

  Science · 2011 · https://doi.org/10.1126/science.1200801

• Frequent Mutation of Isocitrate Dehydrogenase(IDH)1andIDH2in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping

  The Oncologist · 2011 · https://doi.org/10.1634/theoncologist.2011-0386

• Rituximab therapy leads to rapid decline of serum IgG4 levels and prompt clinical improvement in IgG4‐related systemic disease

  Arthritis & Rheumatism · 2010 · 10.1002/art.27435

Current projects

No projects listed.