Pier Paolo Pandolfi

Research interests

Publications

• The functions and regulation of the PTEN tumour suppressor: new modes and prospects

  Nature Reviews Molecular Cell Biology · 2018 · 10.1038/s41580-018-0015-0

• Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity

  Cell · 2015 · https://doi.org/10.1016/j.cell.2015.11.009

• The multilayered complexity of ceRNA crosstalk and competition

  Nature · 2014 · https://doi.org/10.1038/nature12986

• Cancer metabolism: fatty acid oxidation in the limelight

  Nature reviews. Cancer · 2013 · https://doi.org/10.1038/nrc3483

• ceRNA Cross-Talk in Cancer: When ce-bling Rivalries Go Awry

  Cancer Discovery · 2013 · 10.1158/2159-8290.cd-13-0202

• A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

  Nature Medicine · 2012 · https://doi.org/10.1038/nm.2882

• The functions and regulation of the PTEN tumour suppressor

  Nature Reviews Molecular Cell Biology · 2012 · https://doi.org/10.1038/nrm3330

• Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs

  Cell · 2011 · 10.1016/j.cell.2011.09.029

• A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

  Cell · 2011 · 10.1016/j.cell.2011.07.014

• A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

  Nature · 2010 · 10.1038/nature09144

• Tenets of PTEN Tumor Suppression

  Cell · 2008 · 10.1016/j.cell.2008.04.013

• Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

  Journal of Clinical Investigation · 2008 · 10.1172/jci34739

• The PTEN–PI3K pathway: of feedbacks and cross-talks

  Oncogene · 2008 · 10.1038/onc.2008.247

• Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

  Nature Reviews Molecular Cell Biology · 2007 · 10.1038/nrm2277

• Essential Role for Nuclear PTEN in Maintaining Chromosomal Integrity

  Cell · 2007 · 10.1016/j.cell.2006.11.042

• Nucleophosmin and cancer

  Nature reviews. Cancer · 2006 · 10.1038/nrc1885

• Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

  Nature · 2005 · 10.1038/nature03918

• Phosphorylation and Functional Inactivation of TSC2 by Erk

  Cell · 2005 · 10.1016/j.cell.2005.02.031

• Essential role of Plzf in maintenance of spermatogonial stem cells

  Nature Genetics · 2004 · 10.1038/ng1367

• Does the ribosome translate cancer?

  Nature reviews. Cancer · 2003 · 10.1038/nrc1015

• PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

  Nature · 2000 · 10.1038/35018127

• The Multiple Roles of PTEN in Tumor Suppression

  Cell · 2000 · 10.1016/s0092-8674(00)80674-1

• Crystal Structure of the PTEN Tumor Suppressor

  Cell · 1999 · 10.1016/s0092-8674(00)81663-3

• The p66shc adaptor protein controls oxidative stress response and life span in mammals

  Nature · 1999 · 10.1038/46311

• Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide

  New England Journal of Medicine · 1998 · 10.1056/nejm199811053391901

• Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

  Nature Genetics · 1998 · 10.1038/ng0598-56

• Pten is essential for embryonic development and tumour suppression

  Nature Genetics · 1998 · 10.1038/1235

Current projects

No projects listed.