Jaroslaw P. Maciejewski

Research interests

Publications

• Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms

  Blood · 2020 · https://doi.org/10.1182/blood.2019004229

• SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS

  Blood · 2020 · https://doi.org/10.1182/blood.2020004850

• Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation

  Blood · 2017 · https://doi.org/10.1182/blood-2016-12-754796

• Dynamics of clonal evolution in myelodysplastic syndromes

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3742

• Time-dependent changes in mortality and transformation risk in MDS

  Blood · 2016 · https://doi.org/10.1182/blood-2016-02-700054

• Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms

  Cancer Cell · 2015 · https://doi.org/10.1016/j.ccell.2015.03.017

• Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents

  Blood · 2015 · https://doi.org/10.1182/blood-2015-09-669937

• Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia

  New England Journal of Medicine · 2015 · https://doi.org/10.1056/nejmoa1414799

• Baseline characteristics and disease burden in patients in the International Paroxysmal Nocturnal Hemoglobinuria Registry

  Haematologica · 2014 · https://doi.org/10.3324/haematol.2013.093161

• Long‐term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria

  British Journal of Haematology · 2013 · https://doi.org/10.1111/bjh.12347

• Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

  Blood · 2013 · https://doi.org/10.1182/blood-2012-12-474577

• Revised International Prognostic Scoring System for Myelodysplastic Syndromes

  Blood · 2012 · https://doi.org/10.1182/blood-2012-03-420489

• Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis

  Blood · 2012 · https://doi.org/10.1182/blood-2011-12-399774

• Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia

  New England Journal of Medicine · 2012 · https://doi.org/10.1056/nejmoa1114885

• STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia

  Blood · 2012 · https://doi.org/10.1182/blood-2012-06-435297

• Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A

  Blood · 2011 · https://doi.org/10.1182/blood-2010-10-311019

• Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

  Nature · 2010 · https://doi.org/10.1038/nature09586

• Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms

  Blood · 2009 · https://doi.org/10.1182/blood-2009-02-205690

• 250K Single Nucleotide Polymorphism Array Karyotyping Identifies Acquired Uniparental Disomy and Homozygous Mutations, Including Novel Missense Substitutions of c-Cbl , in Myeloid Malignancies

  Cancer Research · 2008 · https://doi.org/10.1158/0008-5472.can-08-2754

• Aberrant DNA methylation is a dominant mechanism in MDS progression to AML

  Blood · 2008 · https://doi.org/10.1182/blood-2008-06-163246

• Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML

  Blood · 2007 · https://doi.org/10.1182/blood-2007-05-092304

• Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria

  Blood · 2007 · https://doi.org/10.1182/blood-2007-06-094136

• Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation

  Blood · 2007 · https://doi.org/10.1182/blood-2007-04-084814

• CD4+CD25high Foxp3+ regulatory T cells in myelodysplastic syndrome (MDS)

  Blood · 2007 · https://doi.org/10.1182/blood-2007-01-067546

• The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria

  New England Journal of Medicine · 2006 · https://doi.org/10.1056/nejmoa061648

• HLA-DR15 (DR2) is overrepresented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome

  Blood · 2002 · https://doi.org/10.1182/blood.v100.5.1570.h81702001570_1570_1574

• Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro

  Blood · 1995 · https://doi.org/10.1182/blood.v85.11.3183.bloodjournal85113183

Current projects

No projects listed.