Stephen B. Baylin

Research interests

Publications

• Pan-cancer analysis of whole genomes

  Nature · 2020 · https://doi.org/10.1038/s41586-020-1969-6

• Comprehensive molecular characterization of mitochondrial genomes in human cancers

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0557-x

• Integrative Molecular Characterization of Malignant Pleural Mesothelioma

  Cancer Discovery · 2018 · https://doi.org/10.1158/2159-8290.cd-18-0804

• Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.09.007

• Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles

  Cell Reports · 2017 · https://doi.org/10.1016/j.celrep.2017.02.033

• Epigenetic Determinants of Cancer

  Cold Spring Harbor Perspectives in Biology · 2016 · 10.1101/cshperspect.a019505

• Targeting the cancer epigenome for therapy

  Nature Reviews Genetics · 2016 · 10.1038/nrg.2016.93

• Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

  Cell · 2015 · 10.1016/j.cell.2015.07.011

• Integrated Genomic Characterization of Papillary Thyroid Carcinoma

  Cell · 2014 · https://doi.org/10.1016/j.cell.2014.09.050

• A decade of exploring the cancer epigenome — biological and translational implications

  Nature reviews. Cancer · 2011 · 10.1038/nrc3130

• Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

  Cancer Cell · 2010 · 10.1016/j.ccr.2010.03.017

• A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

  Nature Genetics · 2007 · 10.1038/ng1972

• The Epigenomics of Cancer

  Cell · 2007 · https://doi.org/10.1016/j.cell.2007.01.029

• Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

  Nature reviews. Cancer · 2006 · 10.1038/nrc1799

• DNA methylation and gene silencing in cancer

  Nature Clinical Practice Oncology · 2005 · 10.1038/ncponc0354

• Gene Silencing in Cancer in Association with Promoter Hypermethylation

  New England Journal of Medicine · 2003 · https://doi.org/10.1056/nejmra023075

• The fundamental role of epigenetic events in cancer

  Nature Reviews Genetics · 2002 · https://doi.org/10.1038/nrg816

• DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

  Nature · 2002 · 10.1038/416552a

• A gene hypermethylation profile of human cancer.

  PubMed · 2001

• Inactivation of the DNA-Repair Gene MGMT and the Clinical Response of Gliomas to Alkylating Agents

  New England Journal of Medicine · 2000 · 10.1056/nejm200011093431901

• DNA hypermethylation in tumorigenesis: epigenetics joins genetics

  Trends in Genetics · 2000 · 10.1016/s0168-9525(99)01971-x

• CpG island methylator phenotype in colorectal cancer

  Proceedings of the National Academy of Sciences · 1999 · 10.1073/pnas.96.15.8681

• Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

  Proceedings of the National Academy of Sciences · 1998 · 10.1073/pnas.95.12.6870

• Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

  PubMed · 1995

• 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

  Nature Medicine · 1995 · 10.1038/nm0795-686

• Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

  Nature Genetics · 1994 · 10.1038/ng0894-536

Current projects

No projects listed.