Denis L. J. Lafontaine

Research interests

Publications

• The nucleolus as a multiphase liquid condensate

  Nature Reviews Molecular Cell Biology · 2020 · https://doi.org/10.1038/s41580-020-0272-6

• The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

  Nucleic Acids Research · 2019 · 10.1093/nar/gkz619

• AlkAniline‐Seq: Profiling of m 7 G and m 3 C RNA Modifications at Single Nucleotide Resolution

  Angewandte Chemie International Edition · 2018 · 10.1002/anie.201810946

• AlkAniline‐Seq: Profiling of m 7 G and m 3 C RNA Modifications at Single Nucleotide Resolution

  Angewandte Chemie International Edition · 2018 · 10.1002/anie.201810946

• Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics

  Biochemical Pharmacology · 2018 · 10.1016/j.bcp.2018.11.014

• Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics

  Biochemical Pharmacology · 2018 · 10.1016/j.bcp.2018.11.014

• Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics

  Biochemical Pharmacology · 2018 · 10.1016/j.bcp.2018.11.014

• AlkAniline‐Seq: Profiling of m 7 G and m 3 C RNA Modifications at Single Nucleotide Resolution

  Angewandte Chemie International Edition · 2018 · 10.1002/anie.201810946

• Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function

  RNA Biology · 2016 · https://doi.org/10.1080/15476286.2016.1259781

• Melanoma addiction to the long non-coding RNA SAMMSON

  Nature · 2016 · https://doi.org/10.1038/nature17161

• Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress

  Nature Communications · 2016 · 10.1038/ncomms11390

• The cell proliferation antigen Ki-67 organises heterochromatin

  eLife · 2016 · 10.7554/elife.13722

• The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis

  Molecular Biology of the Cell · 2015 · 10.1091/mbc.e15-02-0073

• Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1

  Nucleic Acids Research · 2015 · 10.1093/nar/gkv075

• Noncoding RNAs in eukaryotic ribosome biogenesis and function

  Nature Structural & Molecular Biology · 2015 · 10.1038/nsmb.2939

• ‘View From A Bridge’: A New Perspective on Eukaryotic rRNA Base Modification

  Trends in Biochemical Sciences · 2015 · 10.1016/j.tibs.2015.07.008

• The reverse transcription signature ofN-1-methyladenosine in RNA-Seq is sequence dependent

  Nucleic Acids Research · 2015 · 10.1093/nar/gkv895

• The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis

  Molecular Biology of the Cell · 2015 · 10.1091/mbc.e15-02-0073

• The reverse transcription signature ofN-1-methyladenosine in RNA-Seq is sequence dependent

  Nucleic Acids Research · 2015 · 10.1093/nar/gkv895

• The reverse transcription signature ofN-1-methyladenosine in RNA-Seq is sequence dependent

  Nucleic Acids Research · 2015 · 10.1093/nar/gkv895

• The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis

  Molecular Biology of the Cell · 2015 · 10.1091/mbc.e15-02-0073

• A new system for naming ribosomal proteins

  Current Opinion in Structural Biology · 2014 · 10.1016/j.sbi.2014.01.002

• The Complexity of Human Ribosome Biogenesis Revealed by Systematic Nucleolar Screening of Pre-rRNA Processing Factors

  Molecular Cell · 2013 · 10.1016/j.molcel.2013.08.011

• Mapping the cleavage sites on mammalian pre-rRNAs: Where do we stand?

  Biochimie · 2012 · 10.1016/j.biochi.2012.02.001

• The nucleolus: structure/function relationship in RNA metabolism

  Wiley Interdisciplinary Reviews - RNA · 2010 · 10.1002/wrna.39

• Birth of a nucleolus: the evolution of nucleolar compartments

  Trends in Cell Biology · 2005 · 10.1016/j.tcb.2005.02.007

• Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments

  The EMBO Journal · 2002 · 10.1093/emboj/21.11.2736

• Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments

  The EMBO Journal · 2002 · 10.1093/emboj/21.11.2736

• Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments

  The EMBO Journal · 2002 · 10.1093/emboj/21.11.2736

• The Nucle(ol)ar Tif6p and Efl1p Are Required for a Late Cytoplasmic Step of Ribosome Synthesis

  Molecular Cell · 2001 · 10.1016/s1097-2765(01)00403-8

• The Nucle(ol)ar Tif6p and Efl1p Are Required for a Late Cytoplasmic Step of Ribosome Synthesis

  Molecular Cell · 2001 · 10.1016/s1097-2765(01)00403-8

• The function and synthesis of ribosomes

  Nature Reviews Molecular Cell Biology · 2001 · 10.1038/35080045

• The Nucle(ol)ar Tif6p and Efl1p Are Required for a Late Cytoplasmic Step of Ribosome Synthesis

  Molecular Cell · 2001 · 10.1016/s1097-2765(01)00403-8

• Birth of the snoRNPs: the evolution of the modification-guide snoRNAs

  Trends in Biochemical Sciences · 1998 · 10.1016/s0968-0004(98)01260-2

• Birth of the snoRNPs: the evolution of the modification-guide snoRNAs

  Trends in Biochemical Sciences · 1998 · 10.1016/s0968-0004(98)01260-2

• Birth of the snoRNPs: the evolution of the modification-guide snoRNAs

  Trends in Biochemical Sciences · 1998 · 10.1016/s0968-0004(98)01260-2

• The box H+ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase

  Genes & Development · 1998 · 10.1101/gad.12.4.527

• The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast.

  Genes & Development · 1995 · 10.1101/gad.9.20.2470

• The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast.

  Genes & Development · 1995 · 10.1101/gad.9.20.2470

• The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast.

  Genes & Development · 1995 · 10.1101/gad.9.20.2470

• The DIM1 Gene Responsible for the Conserved m62Am62A Dimethylation in the 3′-Terminal Loop of 18 S rRNA is Essential in Yeast

  Journal of Molecular Biology · 1994 · 10.1006/jmbi.1994.1525

• The DIM1 Gene Responsible for the Conserved m62Am62A Dimethylation in the 3′-Terminal Loop of 18 S rRNA is Essential in Yeast

  Journal of Molecular Biology · 1994 · 10.1006/jmbi.1994.1525

• The DIM1 Gene Responsible for the Conserved m62Am62A Dimethylation in the 3′-Terminal Loop of 18 S rRNA is Essential in Yeast

  Journal of Molecular Biology · 1994 · 10.1006/jmbi.1994.1525

Current projects

No projects listed.