Chun Ye

Research interests

Publications

• Genome-wide prediction of disease variant effects with a deep protein language model

  Nature Genetics · 2023 · 10.1038/s41588-023-01465-0

• Single-cell RNA-seq reveals cell type–specific molecular and genetic associations to lupus

  Science · 2022 · 10.1126/science.abf1970

• CRISPR activation and interference screens decode stimulation responses in primary human T cells

  Science · 2022 · 10.1126/science.abj4008

• Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease

  Science · 2022 · https://doi.org/10.1126/science.abf3041

• Evolution of immune genes is associated with the Black Death

  Nature · 2022 · 10.1038/s41586-022-05349-x

• Obesity alters pathology and treatment response in inflammatory disease

  Nature · 2022 · 10.1038/s41586-022-04536-0

• Global absence and targeting of protective immune states in severe COVID-19

  Nature · 2021 · 10.1038/s41586-021-03234-7

• Evaluation of SARS-CoV-2 serology assays reveals a range of test performance

  Nature Biotechnology · 2020 · 10.1038/s41587-020-0659-0

• Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.05.017

• Test performance evaluation of SARS-CoV-2 serological assays

  medRxiv · 2020 · 10.1101/2020.04.25.20074856

• Functional interpretation of single cell similarity maps

  Nature Communications · 2019 · 10.1038/s41467-019-12235-0

• Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity

  Cell · 2019 · 10.1016/j.cell.2019.02.005

• Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

  Immunity · 2018 · 10.1016/j.immuni.2018.04.006

• Multiplexed droplet single-cell RNA-sequencing using natural genetic variation

  Nature Biotechnology · 2017 · https://doi.org/10.1038/nbt.4042

• CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells

  Scientific Reports · 2017 · 10.1038/s41598-017-00462-8

• Discovery of stimulation-responsive immune enhancers with CRISPR activation

  Nature · 2017 · 10.1038/nature23875

• A tissue checkpoint regulates type 2 immunity

  Nature Immunology · 2016 · 10.1038/ni.3582

• Transethnic Genetic-Correlation Estimates from Summary Statistics

  The American Journal of Human Genetics · 2016 · 10.1016/j.ajhg.2016.05.001

• Parsing the Interferon Transcriptional Network and Its Disease Associations

  Cell · 2016 · 10.1016/j.cell.2015.12.032

• A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

  Cell · 2015 · 10.1016/j.cell.2015.06.059

• Generation of knock-in primary human T cells using Cas9 ribonucleoproteins

  Proceedings of the National Academy of Sciences · 2015 · 10.1073/pnas.1512503112

• Intersection of population variation and autoimmunity genetics in human T cell activation

  Science · 2014 · 10.1126/science.1254665

• Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

  Science · 2014 · 10.1126/science.1249547

• Phase structures and electrical properties of new lead-free (Na0.5K0.5)NbO3–(Bi0.5Na0.5)TiO3 ceramics

  Applied Physics Letters · 2007 · 10.1063/1.2710768

• Assessing computational tools for the discovery of transcription factor binding sites

  Nature Biotechnology · 2005 · https://doi.org/10.1038/nbt1053

Current projects

No projects listed.