Deepak Srivastava

Research interests

Publications

• Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration

  Cell · 2018 · 10.1016/j.cell.2018.02.014

• Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3970

• Conversion of human fibroblasts into functional cardiomyocytes by small molecules

  Science · 2016 · 10.1126/science.aaf1502

• The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy

  Nature Medicine · 2016 · https://doi.org/10.1038/nm.4179

• Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness

  Proceedings of the National Academy of Sciences · 2015 · 10.1073/pnas.1508073112

• Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage

  Cell · 2012 · 10.1016/j.cell.2012.07.035

• In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

  Nature · 2012 · 10.1038/nature11044

• Genetics of Human Cardiovascular Disease

  Cell · 2012 · 10.1016/j.cell.2012.03.001

• Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

  Cell · 2010 · https://doi.org/10.1016/j.cell.2010.07.002

• MicroRNAs as Regulators of Differentiation and Cell Fate Decisions

  Cell stem cell · 2010 · 10.1016/j.stem.2010.06.012

• miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

  Nature · 2009 · https://doi.org/10.1038/nature08195

• Cardiac Fibroblasts Regulate Myocardial Proliferation through β1 Integrin Signaling

  Developmental Cell · 2009 · 10.1016/j.devcel.2008.12.007

• miR-126 Regulates Angiogenic Signaling and Vascular Integrity

  Developmental Cell · 2008 · https://doi.org/10.1016/j.devcel.2008.07.008

• MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells

  Cell stem cell · 2008 · 10.1016/j.stem.2008.01.016

• Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2

  Cell · 2007 · 10.1016/j.cell.2007.03.030

• Genetic Basis for Congenital Heart Defects: Current Knowledge

  Circulation · 2007 · 10.1161/circulationaha.106.183056

• Making or Breaking the Heart: From Lineage Determination to Morphogenesis

  Cell · 2006 · 10.1016/j.cell.2006.09.003

• Mutations in NOTCH1 cause aortic valve disease

  Nature · 2005 · 10.1038/nature03940

• MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling

  Proceedings of the National Academy of Sciences · 2005 · 10.1073/pnas.0509535102

• GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

  Nature · 2003 · 10.1038/nature01827

• A genetic blueprint for cardiac development

  Nature · 2000 · 10.1038/35025190

• Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1

  Nature Genetics · 1998 · 10.1038/ng0398-266

• Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

  Nature Genetics · 1997 · 10.1038/ng0697-154

• Molecular Pathways Controlling Heart Development

  Science · 1996 · 10.1126/science.272.5262.671

• A Subclass of bHLH Proteins Required for Cardiac Morphogenesis

  Science · 1995 · 10.1126/science.270.5244.1995

Current projects

No projects listed.