Ko Okumura

Research interests

Publications

• A pilot study of operational tolerance with a regulatory T‐cell‐based cell therapy in living donor liver transplantation

  Hepatology · 2016 · https://doi.org/10.1002/hep.28459

• IL-33 is a crucial amplifier of innate rather than acquired immunity

  Proceedings of the National Academy of Sciences · 2010 · https://doi.org/10.1073/pnas.1003059107

• Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation

  Blood · 2009 · https://doi.org/10.1182/blood-2008-10-185884

• Antimicrobial Peptides Human β-Defensins Stimulate Epidermal Keratinocyte Migration, Proliferation and Production of Proinflammatory Cytokines and Chemokines

  Journal of Investigative Dermatology · 2006 · https://doi.org/10.1038/sj.jid.5700599

• Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9–mediated progenitor cell mobilization

  The Journal of Experimental Medicine · 2005 · https://doi.org/10.1084/jem.20050959

• The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo

  The Journal of Immunology · 2005 · https://doi.org/10.4049/jimmunol.175.4.2340

• Tumor Necrosis Factor α (TNFα) Induces the Unfolded Protein Response (UPR) in a Reactive Oxygen Species (ROS)-dependent Fashion, and the UPR Counteracts ROS Accumulation by TNFα

  Journal of Biological Chemistry · 2005 · https://doi.org/10.1074/jbc.m505818200

• Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity

  Journal of Clinical Investigation · 2002 · https://doi.org/10.1172/jci14704

• Expression of Programmed Death 1 Ligands by Murine T Cells and APC

  The Journal of Immunology · 2002 · https://doi.org/10.4049/jimmunol.169.10.5538

• Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

  The Journal of Experimental Medicine · 2002 · https://doi.org/10.1084/jem.20011171

• Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity

  Journal of Clinical Investigation · 2002 · https://doi.org/10.1172/jci0214704

• Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

  Nature Medicine · 2001 · https://doi.org/10.1038/83416

• Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) Contributes to Interferon γ–Dependent Natural Killer Cell Protection from Tumor Metastasis

  The Journal of Experimental Medicine · 2001 · https://doi.org/10.1084/jem.193.6.661

• Critical contribution of liver natural killer T cells to a murine model of hepatitis

  Proceedings of the National Academy of Sciences · 2000 · https://doi.org/10.1073/pnas.040566697

• Type I Interferons (IFNs) Regulate Tumor Necrosis Factor–related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs

  The Journal of Experimental Medicine · 1999 · https://doi.org/10.1084/jem.189.9.1451

• The Natural Killer T (NKT) Cell Ligand α-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on NKT Cells

  The Journal of Experimental Medicine · 1999 · https://doi.org/10.1084/jem.189.7.1121

• Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

  Proceedings of the National Academy of Sciences · 1998 · https://doi.org/10.1073/pnas.95.7.3537

• CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.

  The Journal of Immunology · 1995 · https://doi.org/10.4049/jimmunol.154.1.97

• Metalloproteinase-mediated release of human Fas ligand.

  The Journal of Experimental Medicine · 1995 · https://doi.org/10.1084/jem.182.6.1777

• The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

  The Journal of Experimental Medicine · 1994 · https://doi.org/10.1084/jem.180.5.1849

• B70 antigen is a second ligand for CTLA-4 and CD28

  Nature · 1993 · https://doi.org/10.1038/366076a0

• Specific Acceptance of Cardiac Allograft After Treatment with Antibodies to ICAM-1 and LFA-1

  Science · 1992 · https://doi.org/10.1126/science.1347662

• Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo.

  The Journal of Immunology · 1983 · https://doi.org/10.4049/jimmunol.131.3.1531

• In vivo effects of anti-asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice.

  The Journal of Immunology · 1981 · https://doi.org/10.4049/jimmunol.127.1.34

• A glycolipid on the surface of mouse natural killer cells

  European Journal of Immunology · 1980 · https://doi.org/10.1002/eji.1830100304

Current projects

No projects listed.