Hans Clevers

Research interests

Publications

• SARS-CoV-2 productively infects human gut enterocytes

  Science · 2020 · https://doi.org/10.1126/science.abc1669

• An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

  Nature Medicine · 2019 · https://doi.org/10.1038/s41591-019-0422-6

• Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

  Cell stem cell · 2019 · https://doi.org/10.1016/j.stem.2019.10.010

• Long‐term expanding human airway organoids for disease modeling

  The EMBO Journal · 2019 · https://doi.org/10.15252/embj.2018100300

• Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

  Cell · 2018 · 10.1016/j.cell.2018.07.009

• Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

  Cancer Discovery · 2018 · https://doi.org/10.1158/2159-8290.cd-18-0349

• Organoids in cancer research

  Nature reviews. Cancer · 2018 · 10.1038/s41568-018-0007-6

• A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

  Cell · 2017 · 10.1016/j.cell.2017.11.010

• Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.05.016

• Interrogating open issues in cancer precision medicine with patient-derived xenografts

  Nature reviews. Cancer · 2017 · 10.1038/nrc.2016.140

• Cancer stem cells revisited

  Nature Medicine · 2017 · 10.1038/nm.4409

• Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

  The Journal of Experimental Medicine · 2017 · 10.1084/jem.20162024

• Modeling Development and Disease with Organoids

  Cell · 2016 · 10.1016/j.cell.2016.05.082

• Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

  Cell · 2015 · 10.1016/j.cell.2015.03.053

• Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

  Cell · 2014 · 10.1016/j.cell.2014.11.050

• Organoid Cultures Derived from Patients with Advanced Prostate Cancer

  Cell · 2014 · 10.1016/j.cell.2014.08.016

• Organoid Models of Human and Mouse Ductal Pancreatic Cancer

  Cell · 2014 · 10.1016/j.cell.2014.12.021

• Wnt/β-Catenin Signaling and Disease

  Cell · 2012 · https://doi.org/10.1016/j.cell.2012.05.012

• ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

  Nature · 2012 · 10.1038/nature11228

• The cancer stem cell: premises, promises and challenges

  Nature Medicine · 2011 · 10.1038/nm.2304

• Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

  Gastroenterology · 2011 · 10.1053/j.gastro.2011.07.050

• Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

  Nature · 2010 · 10.1038/nature09637

• Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

  Cell · 2010 · 10.1016/j.cell.2010.09.016

• Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

  Nature · 2009 · https://doi.org/10.1038/nature07935

• Crypt stem cells as the cells-of-origin of intestinal cancer

  Nature · 2008 · 10.1038/nature07602

• Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

  Annual Review of Physiology · 2008 · 10.1146/annurev.physiol.010908.163145

• Identification of stem cells in small intestine and colon by marker gene Lgr5

  Nature · 2007 · https://doi.org/10.1038/nature06196

• Wnt/β-Catenin Signaling in Development and Disease

  Cell · 2006 · https://doi.org/10.1016/j.cell.2006.10.018

• Wnt signalling in stem cells and cancer

  Nature · 2005 · 10.1038/nature03319

• The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

  Cell · 2002 · 10.1016/s0092-8674(02)01014-0

• Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

  Science · 1997 · 10.1126/science.275.5307.1784

• Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

  Science · 1997 · 10.1126/science.275.5307.1787

• XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

  Cell · 1996 · 10.1016/s0092-8674(00)80112-9

Current projects

No projects listed.