Jian Yang

Research interests

Publications

• Genetic mechanisms of critical illness in COVID-19

  Nature · 2020 · https://doi.org/10.1038/s41586-020-03065-y

• Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

  Nature Metabolism · 2020 · https://doi.org/10.1038/s42255-020-00287-2

• Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

  Genome Medicine · 2019 · https://doi.org/10.1186/s13073-019-0667-1

• Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

  The Lancet Neurology · 2019 · https://doi.org/10.1016/s1474-4422(19)30320-5

• Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-018-0309-3

• Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

  Nature Genetics · 2018 · 10.1038/s41588-018-0147-3

• Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

  Human Molecular Genetics · 2018 · 10.1093/hmg/ddy271

• Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

  Human Molecular Genetics · 2018 · 10.1093/hmg/ddy327

• Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

  Nature Communications · 2018 · 10.1038/s41467-018-04951-w

• Causal associations between risk factors and common diseases inferred from GWAS summary data

  Nature Communications · 2018 · 10.1038/s41467-017-02317-2

• 10 Years of GWAS Discovery: Biology, Function, and Translation

  The American Journal of Human Genetics · 2017 · 10.1016/j.ajhg.2017.06.005

• Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

  Nature Genetics · 2016 · 10.1038/ng.3538

• Biological interpretation of genome-wide association studies using predicted gene functions

  Nature Communications · 2015 · 10.1038/ncomms6890

• Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

  The American Journal of Human Genetics · 2015 · 10.1016/j.ajhg.2015.09.001

• LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

  Nature Genetics · 2015 · 10.1038/ng.3211

• Genetic studies of body mass index yield new insights for obesity biology

  Nature · 2015 · 10.1038/nature14177

• Advantages and pitfalls in the application of mixed-model association methods

  Nature Genetics · 2014 · 10.1038/ng.2876

• Defining the role of common variation in the genomic and biological architecture of adult human height

  Nature Genetics · 2014 · 10.1038/ng.3097

• Genetics of rheumatoid arthritis contributes to biology and drug discovery

  Nature · 2013 · 10.1038/nature12873

• GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

  Science · 2013 · 10.1126/science.1235488

• Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

  Nature Genetics · 2013 · 10.1038/ng.2606

• Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

  Nature Genetics · 2012 · 10.1038/ng.2213

• Five Years of GWAS Discovery

  The American Journal of Human Genetics · 2012 · 10.1016/j.ajhg.2011.11.029

• Genomic inflation factors under polygenic inheritance

  European Journal of Human Genetics · 2011 · 10.1038/ejhg.2011.39

• Genome partitioning of genetic variation for complex traits using common SNPs

  Nature Genetics · 2011 · 10.1038/ng.823

• Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

  Nature Genetics · 2010 · 10.1038/ng.685

• Common SNPs explain a large proportion of the heritability for human height

  Nature Genetics · 2010 · 10.1038/ng.608

• Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

  Nature Genetics · 2010 · 10.1038/ng.686

• Hundreds of variants clustered in genomic loci and biological pathways affect human height

  Nature · 2010 · 10.1038/nature09410

• GCTA: A Tool for Genome-wide Complex Trait Analysis

  The American Journal of Human Genetics · 2010 · 10.1016/j.ajhg.2010.11.011

Current projects

No projects listed.