Philippe L. Bédard

Research interests

Publications

• Tucatinib vs Placebo, Both in Combination With Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients With Brain Metastases

  JAMA Oncology · 2022 · 10.1001/jamaoncol.2022.5610

• Phase I/Ib Clinical Trial of Sabatolimab, an Anti–TIM-3 Antibody, Alone and in Combination with Spartalizumab, an Anti–PD-1 Antibody, in Advanced Solid Tumors

  Clinical Cancer Research · 2021 · 10.1158/1078-0432.ccr-20-4746

• Intracranial Efficacy and Survival With Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2-Positive Breast Cancer With Brain Metastases in the HER2CLIMB Trial

  Journal of Clinical Oncology · 2020 · 10.1200/jco.20.00775

• A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors

  American Journal of Clinical Oncology · 2020 · 10.1097/coc.0000000000000691

• Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab

  Nature Cancer · 2020 · https://doi.org/10.1038/s43018-020-0096-5

• Disease modification and biomarker development in Parkinson disease

  Neurology · 2020 · https://doi.org/10.1212/wnl.0000000000009107

• Small molecules, big impact: 20 years of targeted therapy in oncology

  The Lancet · 2020 · 10.1016/s0140-6736(20)30164-1

• Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer

  New England Journal of Medicine · 2019 · https://doi.org/10.1056/nejmoa1914609

• Novel patterns of response under immunotherapy

  Annals of Oncology · 2019 · 10.1093/annonc/mdz003

• Safety and Antitumor Activity of Pembrolizumab in Patients with Estrogen Receptor–Positive/Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer

  Clinical Cancer Research · 2018 · 10.1158/1078-0432.ccr-17-3452

• Sensitive tumour detection and classification using plasma cell-free DNA methylomes

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0703-0

• A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)

  Annals of Oncology · 2018 · https://doi.org/10.1093/annonc/mdy263

• Neratinib Efficacy and Circulating Tumor DNA Detection of HER2 Mutations in HER2 Nonamplified Metastatic Breast Cancer

  Clinical Cancer Research · 2017 · 10.1158/1078-0432.ccr-17-0900

• AACR Project GENIE: Powering Precision Medicine through an International Consortium

  Cancer Discovery · 2017 · https://doi.org/10.1158/2159-8290.cd-17-0151

• AKT Inhibition in Solid Tumors With AKT1 Mutations

  Journal of Clinical Oncology · 2017 · 10.1200/jco.2017.73.0143

• Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial

  Genome Medicine · 2016 · https://doi.org/10.1186/s13073-016-0364-2

• A systematic review of immune-related adverse event reporting in clinical trials of immune checkpoint inhibitors

  Annals of Oncology · 2015 · 10.1093/annonc/mdv182

• Patterns of Relapse in Patients With Clinical Stage I Testicular Cancer Managed With Active Surveillance

  Journal of Clinical Oncology · 2014 · 10.1200/jco.2014.56.2116

• A Phase Ib Dose-Escalation Study of the Oral Pan-PI3K Inhibitor Buparlisib (BKM120) in Combination with the Oral MEK1/2 Inhibitor Trametinib (GSK1120212) in Patients with Selected Advanced Solid Tumors

  Clinical Cancer Research · 2014 · 10.1158/1078-0432.ccr-14-1814

• Androgen Receptor Expression and Outcomes in Early Breast Cancer: A Systematic Review and Meta-Analysis

  JNCI Journal of the National Cancer Institute · 2013 · 10.1093/jnci/djt319

• Tumour heterogeneity in the clinic

  Nature · 2013 · https://doi.org/10.1038/nature12627

• Cancer Genomics: Technology, Discovery, and Translation

  Journal of Clinical Oncology · 2012 · 10.1200/jco.2011.39.2316

• The Genetic Basis for Cancer Treatment Decisions

  Cell · 2012 · 10.1016/j.cell.2012.01.014

• Elucidating Prognosis and Biology of Breast Cancer Arising in Young Women Using Gene Expression Profiling

  Clinical Cancer Research · 2012 · https://doi.org/10.1158/1078-0432.ccr-11-2599

• Luminal-B breast cancer and novel therapeutic targets

  Breast Cancer Research · 2011 · 10.1186/bcr2904

• International Guidelines for Management of Metastatic Breast Cancer: Combination vs Sequential Single-Agent Chemotherapy

  JNCI Journal of the National Cancer Institute · 2009 · https://doi.org/10.1093/jnci/djp235

Current projects

No projects listed.