John E. Dick

Research interests

Publications

• Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia

  Cancer Discovery · 2021 · https://doi.org/10.1158/2159-8290.cd-21-0145

• Prediction of acute myeloid leukaemia risk in healthy individuals

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0317-6

• Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3691

• A 17-gene stemness score for rapid determination of risk in acute leukaemia

  Nature · 2016 · https://doi.org/10.1038/nature20598

• Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

  Science · 2015 · https://doi.org/10.1126/science.aab2116

• Evolution of the Cancer Stem Cell Model

  Cell stem cell · 2014 · https://doi.org/10.1016/j.stem.2014.02.006

• Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

  Nature · 2014 · https://doi.org/10.1038/nature13038

• The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

  Nature · 2014 · https://doi.org/10.1038/nature13228

• The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

  Nature · 2012 · https://doi.org/10.1038/nature10725

• Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

  Nature Medicine · 2012 · https://doi.org/10.1038/nm.2661

• Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

  Science · 2012 · https://doi.org/10.1126/science.1227670

• Hematopoiesis: A Human Perspective

  Cell stem cell · 2012 · https://doi.org/10.1016/j.stem.2012.01.006

• Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment

  Science · 2011 · https://doi.org/10.1126/science.1201219

• Stem cell gene expression programs influence clinical outcome in human leukemia

  Nature Medicine · 2011 · 10.1038/nm.2415

• Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

  Cancer Cell · 2011 · https://doi.org/10.1016/j.ccr.2011.10.015

• Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay Based on Inductively Coupled Plasma Time-of-Flight Mass Spectrometry

  Analytical Chemistry · 2009 · https://doi.org/10.1021/ac901049w

• Stem cell concepts renew cancer research

  Blood · 2008 · https://doi.org/10.1182/blood-2008-08-077941

• A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

  Nature · 2006 · https://doi.org/10.1038/nature05372

• Cancer Stem Cells—Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells

  Cancer Research · 2006 · https://doi.org/10.1158/0008-5472.can-06-3126

• Targeting of CD44 eradicates human acute myeloid leukemic stem cells

  Nature Medicine · 2006 · https://doi.org/10.1038/nm1483

• Cancer stem cells: lessons from leukemia

  Trends in Cell Biology · 2005 · https://doi.org/10.1016/j.tcb.2005.07.004

• Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity

  Nature Immunology · 2004 · https://doi.org/10.1038/ni1080

• A newly discovered class of human hematopoietic cells with SCID-repopulating activity

  Nature Medicine · 1998 · https://doi.org/10.1038/2023

• Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

  Nature Medicine · 1997 · https://doi.org/10.1038/nm0797-730

• Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice

  Proceedings of the National Academy of Sciences · 1997 · https://doi.org/10.1073/pnas.94.10.5320

• Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy

  Nature Medicine · 1996 · https://doi.org/10.1038/nm1296-1329

• A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

  Nature · 1994 · https://doi.org/10.1038/367645a0

• Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/W mice

  Cell · 1985 · https://doi.org/10.1016/s0092-8674(85)80102-1

Current projects

No projects listed.