Li Ding

Research interests

Publications

• Proteogenomic characterization of pancreatic ductal adenocarcinoma

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.08.023

• Proteogenomic and metabolomic characterization of human glioblastoma

  Cancer Cell · 2021 · https://doi.org/10.1016/j.ccell.2021.01.006

• The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.03.053

• Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.06.013

• Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities

  Cell · 2019 · 10.1016/j.cell.2019.03.030

• Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma

  Cell · 2019 · 10.1016/j.cell.2019.10.007

• Multi-platform discovery of haplotype-resolved structural variation in human genomes

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-018-08148-z

• Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

  Cell · 2019 · 10.1016/j.cell.2019.08.052

• Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

  Cell Systems · 2018 · 10.1016/j.cels.2018.03.002

• Oncogenic Signaling Pathways in The Cancer Genome Atlas

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.03.035

• Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles

  Cell Reports · 2017 · 10.1016/j.celrep.2017.02.033

• Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

  Cell · 2016 · 10.1016/j.cell.2015.12.028

• Proteogenomics connects somatic mutations to signalling in breast cancer

  Nature · 2016 · 10.1038/nature18003

• An integrated map of structural variation in 2,504 human genomes

  Nature · 2015 · 10.1038/nature15394

• Germline Mutations in Predisposition Genes in Pediatric Cancer

  New England Journal of Medicine · 2015 · 10.1056/nejmoa1508054

• Age-related mutations associated with clonal hematopoietic expansion and malignancies

  Nature Medicine · 2014 · 10.1038/nm.3733

• Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

  New England Journal of Medicine · 2014 · 10.1056/nejmoa1403088

• MSIsensor: microsatellite instability detection using paired tumor-normal sequence data

  Bioinformatics · 2013 · 10.1093/bioinformatics/btt755

• Mutational landscape and significance across 12 major cancer types

  Nature · 2013 · https://doi.org/10.1038/nature12634

• The Origin and Evolution of Mutations in Acute Myeloid Leukemia

  Cell · 2012 · 10.1016/j.cell.2012.06.023

• Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

  Nature · 2012 · 10.1038/nature10738

• The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

  Nature · 2012 · 10.1038/nature10725

• Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

  Cell · 2012 · 10.1016/j.cell.2012.08.024

• VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

  Genome Research · 2012 · https://doi.org/10.1101/gr.129684.111

• Whole-genome analysis informs breast cancer response to aromatase inhibition

  Nature · 2012 · 10.1038/nature11143

• Mapping copy number variation by population-scale genome sequencing

  Nature · 2011 · 10.1038/nature09708

• Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

  Cancer Cell · 2010 · 10.1016/j.ccr.2010.03.017

• Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

  Cancer Cell · 2010 · https://doi.org/10.1016/j.ccr.2009.12.020

• Genome remodelling in a basal-like breast cancer metastasis and xenograft

  Nature · 2010 · 10.1038/nature08989

• DNMT3A Mutations in Acute Myeloid Leukemia

  New England Journal of Medicine · 2010 · 10.1056/nejmoa1005143

• BreakDancer: an algorithm for high-resolution mapping of genomic structural variation

  Nature Methods · 2009 · 10.1038/nmeth.1363

• VarScan: variant detection in massively parallel sequencing of individual and pooled samples

  Bioinformatics · 2009 · 10.1093/bioinformatics/btp373

• Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

  New England Journal of Medicine · 2009 · 10.1056/nejmoa0903840

• DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

  Nature · 2008 · 10.1038/nature07485

• Somatic mutations affect key pathways in lung adenocarcinoma

  Nature · 2008 · https://doi.org/10.1038/nature07423

• Characterizing the cancer genome in lung adenocarcinoma

  Nature · 2007 · 10.1038/nature06358

Current projects

No projects listed.