David S. Knopman

Research interests

Publications

• Temporal order of clinical and biomarker changes in familial frontotemporal dementia

  Nature Medicine · 2022 · https://doi.org/10.1038/s41591-022-01942-9

• Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease

  Nature Communications · 2022 · https://doi.org/10.1038/s41467-022-34129-4

• Alzheimer disease

  Nature Reviews Disease Primers · 2021 · https://doi.org/10.1038/s41572-021-00269-y

• Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration

  Neurology · 2021 · https://doi.org/10.1212/wnl.0000000000011848

• Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

  Scientific Reports · 2020 · https://doi.org/10.1038/s41598-020-59669-x

• Cerebral small vessel disease genomics and its implications across the lifespan

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-19111-2

• Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-14159-1

• Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-15701-2

• The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-09564-5

• Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study

  The Lancet Neurology · 2019 · https://doi.org/10.1016/s1474-4422(19)30394-1

• Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

  Acta Neuropathologica · 2019 · https://doi.org/10.1007/s00401-019-01962-9

• Plasma and CSF neurofilament light

  Neurology · 2019 · https://doi.org/10.1212/wnl.0000000000007767

• A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

  Acta Neuropathologica · 2019 · https://doi.org/10.1007/s00401-019-02026-8

• Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer’s Disease using structural MR and FDG-PET images

  Scientific Reports · 2018 · https://doi.org/10.1038/s41598-018-22871-z

• Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition

  JAMA · 2017 · https://doi.org/10.1001/jama.2017.3090

• Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms13249

• Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms11934

• Defining imaging biomarker cut points for brain aging and Alzheimer's disease

  Alzheimer s & Dementia · 2016 · 10.1016/j.jalz.2016.08.005

• A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

  Neurology · 2016 · https://doi.org/10.1212/wnl.0000000000002923

• PART, a distinct tauopathy, different from classical sporadic Alzheimer disease

  Acta Neuropathologica · 2015 · https://doi.org/10.1007/s00401-015-1407-2

• Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

  Nature Communications · 2015 · https://doi.org/10.1038/ncomms7760

• Primary age-related tauopathy (PART): a common pathology associated with human aging

  Acta Neuropathologica · 2014 · 10.1007/s00401-014-1349-0

• Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial

  The Lancet Neurology · 2013 · https://doi.org/10.1016/s1474-4422(12)70320-4

• Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

  The Lancet Neurology · 2013 · 10.1016/s1474-4422(12)70291-0

• Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

  Neuron · 2011 · https://doi.org/10.1016/j.neuron.2011.09.011

• Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

  Brain · 2011 · https://doi.org/10.1093/brain/awr179

• The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

  Alzheimer s & Dementia · 2011 · https://doi.org/10.1016/j.jalz.2011.03.005

• Classification of primary progressive aphasia and its variants

  Neurology · 2011 · https://doi.org/10.1212/wnl.0b013e31821103e6

• Introduction to the recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

  Alzheimer s & Dementia · 2011 · 10.1016/j.jalz.2011.03.004

• Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

  The Lancet Neurology · 2009 · https://doi.org/10.1016/s1474-4422(09)70299-6

• Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease

  Brain · 2009 · 10.1093/brain/awp062

• Mild Cognitive Impairment

  Archives of Neurology · 2009 · 10.1001/archneurol.2009.266

• 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment

  Brain · 2008 · 10.1093/brain/awm336

• Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD

  Neurology · 2004 · 10.1212/01.wnl.0000110315.26026.ef

• Practice parameter: Diagnosis of dementia (an evidence-based review)

  Neurology · 2001 · 10.1212/wnl.56.9.1143

Current projects

No projects listed.