Lewis R. Roberts

Research interests

Publications

• Elevated rates of horizontal gene transfer in the industrialized human microbiome

  Cell · 2021 · 10.1016/j.cell.2021.02.052

• Trial Design and Endpoints in Hepatocellular Carcinoma: AASLD Consensus Conference

  Hepatology · 2020 · 10.1002/hep.31327

• Cholangiocarcinoma 2020: the next horizon in mechanisms and management

  Nature Reviews Gastroenterology & Hepatology · 2020 · https://doi.org/10.1038/s41575-020-0310-z

• Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma

  Journal of Hepatology · 2020 · 10.1016/j.jhep.2020.03.008

• A global view of hepatocellular carcinoma: trends, risk, prevention and management

  Nature Reviews Gastroenterology & Hepatology · 2019 · https://doi.org/10.1038/s41575-019-0186-y

• Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.03.022

• Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

  Cell Reports · 2018 · https://doi.org/10.1016/j.celrep.2018.03.063

• The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

  Cell Reports · 2018 · https://doi.org/10.1016/j.celrep.2018.03.075

• Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases

  Hepatology · 2018 · https://doi.org/10.1002/hep.29913

• Imaging for the diagnosis of hepatocellular carcinoma: A systematic review and meta‐analysis

  Hepatology · 2017 · 10.1002/hep.29487

• AASLD guidelines for the treatment of hepatocellular carcinoma

  Hepatology · 2017 · 10.1002/hep.29086

• Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

  Scientific Reports · 2015 · 10.1038/srep14752

• Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study

  Liver International · 2015 · 10.1111/liv.12818

• The role of hepatic resection in the treatment of hepatocellular cancer

  Hepatology · 2015 · 10.1002/hep.27745

• Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma

  Human Pathology · 2014 · 10.1016/j.humpath.2014.03.014

• Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

  Nature Genetics · 2013 · 10.1038/ng.2813

• Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

  Oncogene · 2012 · 10.1038/onc.2012.315

• Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors

  Gastroenterology · 2011 · 10.1053/j.gastro.2011.12.005

• Hepatocellular carcinoma: a global view

  Nature Reviews Gastroenterology & Hepatology · 2010 · 10.1038/nrgastro.2010.100

• The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets

  Seminars in Cancer Biology · 2010 · 10.1016/j.semcancer.2010.10.007

• α-Fetoprotein, Des-γ Carboxyprothrombin, and Lectin-Bound α-Fetoprotein in Early Hepatocellular Carcinoma

  Gastroenterology · 2009 · 10.1053/j.gastro.2009.04.005

• Association of MicroRNA Expression in Hepatocellular Carcinomas with Hepatitis Infection, Cirrhosis, and Patient Survival

  Clinical Cancer Research · 2008 · 10.1158/1078-0432.ccr-07-0523

• Advanced Cytologic Techniques for the Detection of Malignant Pancreatobiliary Strictures

  Gastroenterology · 2006 · 10.1053/j.gastro.2006.08.021

• A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells

  Nature Medicine · 2006 · 10.1038/nm1377

• Hepatocellular Carcinoma: Molecular Pathways and New Therapeutic Targets

  Seminars in Liver Disease · 2005 · 10.1055/s-2005-871200

• A Comparison of Routine Cytology and Fluorescence in situ Hybridization for the Detection of Malignant Bile Duct Strictures

  The American Journal of Gastroenterology · 2004 · 10.1111/j.1572-0241.2004.30281.x

• Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

  Oncogene · 2002 · 10.1038/sj.onc.1205591

Current projects

No projects listed.