Folkert Kuipers

Research interests

Publications

• Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

  Nature Medicine · 2022 · https://doi.org/10.1038/s41591-022-02014-8

• Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

  Aging Cell · 2019 · 10.1111/acel.12950

• A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis

  Circulation Research · 2019 · 10.1161/circresaha.118.313234

• Beyond intestinal soap—bile acids in metabolic control

  Nature Reviews Endocrinology · 2014 · 10.1038/nrendo.2014.60

• Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

  Diabetes · 2011 · 10.2337/db11-0030

• Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

  Physiological Reviews · 2009 · https://doi.org/10.1152/physrev.00010.2008

• Regulatory enzymes of mitochondrial β‐oxidation as targets for treatment of the metabolic syndrome

  Obesity Reviews · 2009 · 10.1111/j.1467-789x.2009.00642.x

• Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity

  Diabetes · 2007 · https://doi.org/10.2337/db06-1619

• 24(S)-Hydroxycholesterol Participates in a Liver X Receptor-controlled Pathway in Astrocytes That Regulates Apolipoprotein E-mediated Cholesterol Efflux

  Journal of Biological Chemistry · 2006 · 10.1074/jbc.m601019200

• The Farnesoid X Receptor Modulates Adiposity and Peripheral Insulin Sensitivity in Mice

  Journal of Biological Chemistry · 2006 · 10.1074/jbc.m510258200

• The Farnesoid X Receptor

  Arteriosclerosis Thrombosis and Vascular Biology · 2005 · 10.1161/01.atv.0000178994.21828.a7

• The Farnesoid X Receptor Modulates Hepatic Carbohydrate Metabolism during the Fasting-Refeeding Transition

  Journal of Biological Chemistry · 2005 · 10.1074/jbc.m501931200

• The Fasting-induced Adipose Factor/Angiopoietin-like Protein 4 Is Physically Associated with Lipoproteins and Governs Plasma Lipid Levels and Adiposity

  Journal of Biological Chemistry · 2005 · 10.1074/jbc.m506519200

• Glucose Regulates the Expression of the Farnesoid X Receptor in Liver

  Diabetes · 2004 · 10.2337/diabetes.53.4.890

• Hepatic Steatosis: A Mediator of the Metabolic Syndrome. Lessons From Animal Models

  Arteriosclerosis Thrombosis and Vascular Biology · 2004 · 10.1161/01.atv.0000116217.57583.6e

• Differential Effects of Scavenger Receptor BI Deficiency on Lipid Metabolism in Cells of the Arterial Wall and in the Liver

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.m211233200

• Enterohepatic Circulation of Bile Salts in Farnesoid X Receptor-deficient Mice

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.m306309200

• Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

  Journal of Clinical Investigation · 2002 · 10.1172/jci0214505

• Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

  Journal of Clinical Investigation · 2002 · 10.1172/jci14505

• The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

  Proceedings of the National Academy of Sciences · 2002 · https://doi.org/10.1073/pnas.202607599

• Stimulation of Lipogenesis by Pharmacological Activation of the Liver X Receptor Leads to Production of Large, Triglyceride-rich Very Low Density Lipoprotein Particles

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.m204887200

• Fibrates Suppress Bile Acid Synthesis via Peroxisome Proliferator–Activated Receptor-α–Mediated Downregulation of Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase Expression

  Arteriosclerosis Thrombosis and Vascular Biology · 2001 · 10.1161/hq1101.098228

• Copper-induced apical trafficking of ATP7B in polarized hepatoma cells provides a mechanism for biliary copper excretion

  Gastroenterology · 2000 · 10.1053/gast.2000.17834

• Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis

  Gastroenterology · 1999 · https://doi.org/10.1016/s0016-5085(99)70287-8

• Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytes.

  Journal of Clinical Investigation · 1997 · https://doi.org/10.1172/jci119841

• Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport

  Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · 1995 · https://doi.org/10.1016/0304-4157(95)00006-d

Current projects

No projects listed.