Alexandra Zhernakova

Research interests

Publications

• Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

  Nature Metabolism · 2020 · https://doi.org/10.1038/s42255-020-00287-2

• Interaction between drugs and the gut microbiome

  Gut · 2020 · https://doi.org/10.1136/gutjnl-2019-320204

• Impact of commonly used drugs on the composition and metabolic function of the gut microbiota

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-14177-z

• The neuroactive potential of the human gut microbiota in quality of life and depression

  Nature Microbiology · 2019 · https://doi.org/10.1038/s41564-018-0337-x

• Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-019-0350-x

• Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls

  Biological Psychiatry · 2019 · https://doi.org/10.1016/j.biopsych.2019.08.016

• Gut microbiome structure and metabolic activity in inflammatory bowel disease

  Nature Microbiology · 2018 · https://doi.org/10.1038/s41564-018-0306-4

• Environment dominates over host genetics in shaping human gut microbiota

  Nature · 2018 · https://doi.org/10.1038/nature25973

• DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation

  The American Journal of Human Genetics · 2017 · https://doi.org/10.1016/j.ajhg.2017.09.028

• Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

  Science · 2016 · 10.1126/science.aad3369

• Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

  Nature · 2016 · 10.1038/nature20784

• Disease variants alter transcription factor levels and methylation of their binding sites

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3721

• Population-level analysis of gut microbiome variation

  Science · 2016 · https://doi.org/10.1126/science.aad3503

• Identification of context-dependent expression quantitative trait loci in whole blood

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3737

• Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

  Cell · 2016 · 10.1016/j.cell.2016.10.020

• The effect of host genetics on the gut microbiome

  Nature Genetics · 2016 · 10.1038/ng.3663

• Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

  Gut · 2016 · 10.1136/gutjnl-2016-312135

• The transcriptional landscape of age in human peripheral blood

  Nature Communications · 2015 · https://doi.org/10.1038/ncomms9570

• Proton pump inhibitors affect the gut microbiome

  Gut · 2015 · 10.1136/gutjnl-2015-310376

• The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids

  Circulation Research · 2015 · 10.1161/circresaha.115.306807

• Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1

  Gastroenterology · 2014 · https://doi.org/10.1053/j.gastro.2014.04.022

• Systematic identification of trans eQTLs as putative drivers of known disease associations

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2756

• Genetics of rheumatoid arthritis contributes to biology and drug discovery

  Nature · 2013 · https://doi.org/10.1038/nature12873

• High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

  Nature Genetics · 2012 · 10.1038/ng.2462

• Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

  Nature Genetics · 2011 · 10.1038/ng.998

• Multiple common variants for celiac disease influencing immune gene expression

  Nature Genetics · 2010 · 10.1038/ng.543

• Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

  Nature Genetics · 2010 · 10.1038/ng.582

Current projects

No projects listed.