Linas Mažutis

Research interests

Publications

• Progressive plasticity during colorectal cancer metastasis

  Nature · 2024 · https://doi.org/10.1038/s41586-024-08150-0

• Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis

  Science · 2023 · https://doi.org/10.1126/science.add5327

• Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling

  Science · 2022 · https://doi.org/10.1126/science.abn0478

• Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer

  Cancer Cell · 2021 · https://doi.org/10.1016/j.ccell.2021.09.008

• Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease

  Nature Neuroscience · 2021 · https://doi.org/10.1038/s41593-020-00796-z

• A gene–environment-induced epigenetic program initiates tumorigenesis

  Nature · 2021 · https://doi.org/10.1038/s41586-020-03147-x

• Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

  Cancer Cell · 2020 · https://doi.org/10.1016/j.ccell.2020.06.012

• Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition

  Nature · 2020 · https://doi.org/10.1038/s41586-019-1884-x

• Regenerative lineages and immune-mediated pruning in lung cancer metastasis

  Nature Medicine · 2020 · https://doi.org/10.1038/s41591-019-0750-6

• Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis

  Science · 2020 · https://doi.org/10.1126/science.aaz2193

• Regenerative potential of prostate luminal cells revealed by single-cell analysis

  Science · 2020 · https://doi.org/10.1126/science.aay0267

• Characterization of cell fate probabilities in single-cell data with Palantir

  Nature Biotechnology · 2019 · https://doi.org/10.1038/s41587-019-0068-4

• Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

  Cell · 2019 · https://doi.org/10.1016/j.cell.2019.09.035

• Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.05.060

• Recovering Gene Interactions from Single-Cell Data Using Data Diffusion

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.05.061

• Single-cell barcoding and sequencing using droplet microfluidics

  Nature Protocols · 2016 · https://doi.org/10.1038/nprot.2016.154

• Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

  Cell · 2015 · https://doi.org/10.1016/j.cell.2015.04.044

• Platelet bioreactor-on-a-chip

  Blood · 2014 · https://doi.org/10.1182/blood-2014-05-574913

• Single-cell analysis and sorting using droplet-based microfluidics

  Nature Protocols · 2013 · https://doi.org/10.1038/nprot.2013.046

• Quantitative and sensitive detection of rare mutations using droplet-based microfluidics

  Lab on a Chip · 2011 · https://doi.org/10.1039/c1lc20128j

• Droplet-Based Microfluidic Systems for High-Throughput Single DNA Molecule Isothermal Amplification and Analysis

  Analytical Chemistry · 2009 · https://doi.org/10.1021/ac900403z

• Multi-step microfluidic droplet processing: kinetic analysis of an in vitro translated enzyme

  Lab on a Chip · 2009 · https://doi.org/10.1039/b907753g

Current projects

No projects listed.