Craig B. Thompson

Research interests

Publications

• Role of Mitochondria in Ferroptosis

  Molecular Cell · 2018 · 10.1016/j.molcel.2018.10.042

• The Emerging Hallmarks of Cancer Metabolism

  Cell Metabolism · 2016 · https://doi.org/10.1016/j.cmet.2015.12.006

• Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

  Cancer Research · 2015 · https://doi.org/10.1158/0008-5472.can-14-2211

• Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

  Nature · 2014 · https://doi.org/10.1038/nature13981

• Quantitative flux analysis reveals folate-dependent NADPH production

  Nature · 2014 · https://doi.org/10.1038/nature13236

• Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

  Nature · 2013 · https://doi.org/10.1038/nature12138

• IDH mutation impairs histone demethylation and results in a block to cell differentiation

  Nature · 2012 · 10.1038/nature10860

• Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

  Cancer Cell · 2012 · 10.1016/j.ccr.2012.02.014

• IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

  Nature · 2012 · 10.1038/nature10866

• Glutamine addiction: a new therapeutic target in cancer

  Trends in Biochemical Sciences · 2010 · 10.1016/j.tibs.2010.05.003

• Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

  Cancer Cell · 2010 · 10.1016/j.ccr.2010.11.015

• The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

  Cancer Cell · 2010 · 10.1016/j.ccr.2010.01.020

• Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

  Nature · 2009 · https://doi.org/10.1038/nature08617

• ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

  Science · 2009 · 10.1126/science.1164097

• Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

  Science · 2009 · https://doi.org/10.1126/science.1160809

• Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

  Proceedings of the National Academy of Sciences · 2008 · 10.1073/pnas.0810199105

• The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

  Cell Metabolism · 2008 · https://doi.org/10.1016/j.cmet.2007.10.002

• Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

  Proceedings of the National Academy of Sciences · 2007 · 10.1073/pnas.0709747104

• AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint

  Molecular Cell · 2005 · 10.1016/j.molcel.2005.03.027

• An inhibitor of Bcl-2 family proteins induces regression of solid tumours

  Nature · 2005 · 10.1038/nature03579

• Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

  Cancer Cell · 2005 · 10.1016/j.ccr.2004.11.022

• CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

  Molecular and Cellular Biology · 2005 · 10.1128/mcb.25.21.9543-9553.2005

• Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

  Science · 2001 · 10.1126/science.1059108

• Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4

  Science · 1995 · 10.1126/science.270.5238.985

• Apoptosis in the Pathogenesis and Treatment of Disease

  Science · 1995 · https://doi.org/10.1126/science.7878464

• Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

  Cell · 1995 · 10.1016/0092-8674(95)90411-5

• CTLA-4 can function as a negative regulator of T cell activation

  Immunity · 1994 · 10.1016/1074-7613(94)90071-x

• bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

  Cell · 1993 · 10.1016/0092-8674(93)90508-n

Current projects

No projects listed.