Nikolaus Schultz

Research interests

Publications

• Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

  Cell · 2022 · https://doi.org/10.1016/j.cell.2022.01.003

• Genomic correlates of clinical outcome in advanced prostate cancer

  Proceedings of the National Academy of Sciences · 2019 · https://doi.org/10.1073/pnas.1902651116

• The long tail of oncogenic drivers in prostate cancer

  Nature Genetics · 2018 · https://doi.org/10.1038/s41588-018-0078-z

• Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention

  Clinical Cancer Research · 2018 · https://doi.org/10.1158/1078-0432.ccr-18-0078

• Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

  Cell Reports · 2018 · 10.1016/j.celrep.2018.01.088

• Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

  Cancer Cell · 2018 · https://doi.org/10.1016/j.ccell.2018.07.001

• An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.02.052

• Molecular Determinants of Response to Anti–Programmed Cell Death (PD)-1 and Anti–Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non–Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing

  Journal of Clinical Oncology · 2018 · 10.1200/jco.2017.75.3384

• Genomic and Functional Approaches to Understanding Cancer Aneuploidy

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.03.007

• The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.08.008

• Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

  Cell Systems · 2018 · 10.1016/j.cels.2018.03.002

• Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

  Cancer Cell · 2018 · 10.1016/j.ccell.2017.12.004

• Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

  Cell Reports · 2018 · 10.1016/j.celrep.2018.03.050

• A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)

  Annals of Oncology · 2018 · 10.1093/annonc/mdy263

• lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.03.006

• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

  Nature Medicine · 2017 · 10.1038/nm.4333

• AACR Project GENIE: Powering Precision Medicine through an International Consortium

  Cancer Discovery · 2017 · 10.1158/2159-8290.cd-17-0151

• OncoKB: A Precision Oncology Knowledge Base

  JCO Precision Oncology · 2017 · 10.1200/po.17.00011

• Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

  New England Journal of Medicine · 2016 · 10.1056/nejmoa1603144

• Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers

  Journal of Clinical Investigation · 2016 · 10.1172/jci85271

• Integrative Clinical Genomics of Advanced Prostate Cancer

  Cell · 2015 · 10.1016/j.cell.2015.05.001

• Comprehensive molecular characterization of gastric adenocarcinoma

  Nature · 2014 · https://doi.org/10.1038/nature13480

• Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

  Science Signaling · 2013 · https://doi.org/10.1126/scisignal.2004088

• Evaluating cell lines as tumour models by comparison of genomic profiles

  Nature Communications · 2013 · 10.1038/ncomms3126

• Emerging landscape of oncogenic signatures across human cancers

  Nature Genetics · 2013 · 10.1038/ng.2762

• The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

  Cancer Discovery · 2012 · https://doi.org/10.1158/2159-8290.cd-12-0095

• Integrative Genomic Profiling of Human Prostate Cancer

  Cancer Cell · 2010 · https://doi.org/10.1016/j.ccr.2010.05.026

• Pathway Commons, a web resource for biological pathway data

  Nucleic Acids Research · 2010 · 10.1093/nar/gkq1039

Current projects

No projects listed.