Jorge S. Reis‐Filho

Research interests

Publications

• Pathogenesis of Triple-Negative Breast Cancer

  Annual Review of Pathology Mechanisms of Disease · 2022 · 10.1146/annurev-pathol-042420-093238

• Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

  Cell · 2022 · https://doi.org/10.1016/j.cell.2022.01.003

• ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: a report from the ESMO Precision Medicine Working Group

  Annals of Oncology · 2022 · https://doi.org/10.1016/j.annonc.2022.05.520

• High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants

  Nature Medicine · 2019 · 10.1038/s41591-019-0652-7

• The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers

  Cancer Cell · 2018 · https://doi.org/10.1016/j.ccell.2018.08.008

• Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non–Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourina

  Advances in Anatomic Pathology · 2017 · https://doi.org/10.1097/pap.0000000000000161

• Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research

  Advances in Anatomic Pathology · 2017 · https://doi.org/10.1097/pap.0000000000000162

• Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non–Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors

  Advances in Anatomic Pathology · 2017 · 10.1097/pap.0000000000000161

• Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer

  Science Translational Medicine · 2015 · 10.1126/scitranslmed.aab0021

• Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma

  Nature Communications · 2015 · 10.1038/ncomms9839

• The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014

  Annals of Oncology · 2014 · 10.1093/annonc/mdu450

• Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data

  The Lancet Oncology · 2014 · 10.1016/s1470-2045(14)70069-5

• The landscape of cancer genes and mutational processes in breast cancer

  Nature · 2012 · 10.1038/nature11017

• RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors

  New England Journal of Medicine · 2012 · 10.1056/nejmoa1105358

• Gene expression profiling in breast cancer: classification, prognostication, and prediction

  The Lancet · 2011 · 10.1016/s0140-6736(11)61539-0

• Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

  Cell · 2010 · 10.1016/j.cell.2009.12.040

• Triple-Negative Breast Cancer

  New England Journal of Medicine · 2010 · 10.1056/nejmra1001389

• Breast cancer prognostic classification in the molecular era: the role of histological grade

  Breast Cancer Research · 2010 · 10.1186/bcr2607

• BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells

  Cell stem cell · 2010 · 10.1016/j.stem.2010.07.010

• FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer

  Cancer Research · 2010 · 10.1158/0008-5472.can-09-3746

• Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists

  Modern Pathology · 2010 · 10.1038/modpathol.2010.200

• Complex landscapes of somatic rearrangement in human breast cancer genomes

  Nature · 2009 · 10.1038/nature08645

• Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

  Cancer Cell · 2009 · 10.1016/j.ccr.2009.02.022

• Resistance to therapy caused by intragenic deletion in BRCA2

  Nature · 2008 · 10.1038/nature06548

• Basal-Like Breast Cancer: A Critical Review

  Journal of Clinical Oncology · 2008 · 10.1200/jco.2007.13.1748

• Prediction of BRCA1 Status in Patients with Breast Cancer Using Estrogen Receptor and Basal Phenotype

  Clinical Cancer Research · 2005 · 10.1158/1078-0432.ccr-04-2424

Current projects

No projects listed.