Luis A. Díaz

Research interests

Publications

• Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-label, phase 3 study

  The Lancet Oncology · 2022 · https://doi.org/10.1016/s1470-2045(22)00197-8

• PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer

  New England Journal of Medicine · 2022 · 10.1056/nejmoa2201445

• Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer

  New England Journal of Medicine · 2020 · https://doi.org/10.1056/nejmoa2017699

• Cancer therapy shapes the fitness landscape of clonal hematopoiesis

  Nature Genetics · 2020 · 10.1038/s41588-020-00710-0

• Immunotherapy in colorectal cancer: rationale, challenges and potential

  Nature Reviews Gastroenterology & Hepatology · 2019 · 10.1038/s41575-019-0126-x

• Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study

  Journal of Clinical Oncology · 2019 · https://doi.org/10.1200/jco.19.02105

• High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants

  Nature Medicine · 2019 · https://doi.org/10.1038/s41591-019-0652-7

• Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability–High/Mismatch Repair–Deficient Metastatic Colorectal Cancer: KEYNOTE-164

  Journal of Clinical Oncology · 2019 · https://doi.org/10.1200/jco.19.02107

• Detection and localization of surgically resectable cancers with a multi-analyte blood test

  Science · 2018 · 10.1126/science.aar3247

• Cancer-Associated Mutations in Endometriosis without Cancer

  New England Journal of Medicine · 2017 · 10.1056/nejmoa1614814

• Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

  Science · 2017 · 10.1126/science.aan6733

• Direct detection of early-stage cancers using circulating tumor DNA

  Science Translational Medicine · 2017 · 10.1126/scitranslmed.aan2415

• Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

  Science Translational Medicine · 2016 · 10.1126/scitranslmed.aaf6219

• Fulminant Myocarditis with Combination Immune Checkpoint Blockade

  New England Journal of Medicine · 2016 · 10.1056/nejmoa1609214

• Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

  Cancer Discovery · 2016 · 10.1158/2159-8290.cd-16-1223

• PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

  New England Journal of Medicine · 2015 · 10.1056/nejmoa1500596

• Liquid Biopsies: Genotyping Circulating Tumor DNA

  Journal of Clinical Oncology · 2014 · 10.1200/jco.2012.45.2011

• Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

  Science Translational Medicine · 2014 · 10.1126/scitranslmed.3007094

• TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1303607110

• Cancer Genome Landscapes

  Science · 2013 · 10.1126/science.1235122

• The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

  Nature · 2012 · 10.1038/nature11219

• DAXX / ATRX , MEN1 , and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

  Science · 2011 · 10.1126/science.1200609

• Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma

  Science · 2010 · 10.1126/science.1196333

• An Integrated Genomic Analysis of Human Glioblastoma Multiforme

  Science · 2008 · 10.1126/science.1164382

• Circulating mutant DNA to assess tumor dynamics

  Nature Medicine · 2008 · 10.1038/nm.1789

• The colorectal microRNAome

  Proceedings of the National Academy of Sciences · 2006 · 10.1073/pnas.0511155103

• Mutant PIK3CA promotes cell growth and invasion of human cancer cells

  Cancer Cell · 2005 · 10.1016/j.ccr.2005.05.014

• Detection and quantification of mutations in the plasma of patients with colorectal tumors

  Proceedings of the National Academy of Sciences · 2005 · 10.1073/pnas.0507904102

Current projects

No projects listed.