Caroline Graff

Research interests

Publications

• Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

  Nature Communications · 2021 · 10.1038/s41467-021-22491-8

• Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia

  Journal of Neurology Neurosurgery & Psychiatry · 2020 · 10.1136/jnnp-2019-321954

• PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

  Stem Cell Reports · 2019 · 10.1016/j.stemcr.2019.08.004

• Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study

  The Lancet Neurology · 2019 · 10.1016/s1474-4422(19)30394-1

• Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-05892-0

• Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study

  The Lancet Neurology · 2017 · 10.1016/s1474-4422(17)30400-3

• Patterns of gray matter atrophy in genetic frontotemporal dementia: results from the GENFI study

  Neurobiology of Aging · 2017 · 10.1016/j.neurobiolaging.2017.10.008

• Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy

  Acta Neuropathologica Communications · 2016 · 10.1186/s40478-016-0292-9

• Neurofilament light chain: a biomarker for genetic frontotemporal dementia

  Annals of Clinical and Translational Neurology · 2016 · 10.1002/acn3.325

• Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease

  Brain · 2016 · 10.1093/brain/awv404

• Defeating Alzheimer's disease and other dementias: a priority for European science and society

  The Lancet Neurology · 2016 · https://doi.org/10.1016/s1474-4422(16)00062-4

• Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis

  The Lancet Neurology · 2015 · 10.1016/s1474-4422(14)70324-2

• Resolution of inflammation is altered in Alzheimer's disease

  Alzheimer s & Dementia · 2014 · 10.1016/j.jalz.2013.12.024

• Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies

  Human Molecular Genetics · 2014 · 10.1093/hmg/ddu334

• Amyloid-β Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation

  Cell Metabolism · 2014 · 10.1016/j.cmet.2014.07.024

• Modulation of the endoplasmic reticulum–mitochondria interface in Alzheimer’s disease and related models

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1300677110

• A Pan‐ E uropean Study of the C9orf72 Repeat Associated with FTLD : Geographic Prevalence, Genomic Instability, and Intermediate Repeats

  Human Mutation · 2012 · 10.1002/humu.22244

• Association of TMEM106B Gene Polymorphism With Age at Onset in Granulin Mutation Carriers and Plasma Granulin Protein Levels

  Archives of Neurology · 2011 · 10.1001/archneurol.2010.350

• Feeding Cues Alter Clock Gene Oscillations and Photic Responses in the Suprachiasmatic Nuclei of Mice Exposed to a Light/Dark Cycle

  Journal of Neuroscience · 2005 · 10.1523/jneurosci.4397-04.2005

• Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment

  Journal of Internal Medicine · 2004 · https://doi.org/10.1111/j.1365-2796.2004.01380.x

• Increased mitochondrial mass in mitochondrial myopathy mice

  Proceedings of the National Academy of Sciences · 2002 · 10.1073/pnas.232591499

• Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes

  Nature Genetics · 2000 · 10.1038/81649

• Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees

  Science · 2000 · 10.1126/science.290.5500.2303

• Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression

  Nature Genetics · 1999 · 10.1038/5089

• Normative Data for the Mattis Dementia Rating Scale

  Journal of Clinical and Experimental Neuropsychology · 1998 · 10.1076/jcen.20.4.536.1469

Current projects

No projects listed.