Julian C. Knight

Research interests

Publications

• GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

  Nature · 2023 · https://doi.org/10.1038/s41586-023-06034-3

• Whole-genome sequencing reveals host factors underlying critical COVID-19

  Nature · 2022 · https://doi.org/10.1038/s41586-022-04576-6

• Redefining critical illness

  Nature Medicine · 2022 · https://doi.org/10.1038/s41591-022-01843-x

• Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.02.037

• Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00913-z

• Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.06.020

• Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-25167-5

• Antibody evasion by the P.1 strain of SARS-CoV-2

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.03.055

• Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

  Nature Immunology · 2020 · https://doi.org/10.1038/s41590-020-0782-6

• Genetic mechanisms of critical illness in COVID-19

  Nature · 2020 · 10.1038/s41586-020-03065-y

• The Polygenic and Monogenic Basis of Blood Traits and Diseases

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.08.008

• Genetic mechanisms of critical illness in Covid-19

  medRxiv · 2020 · https://doi.org/10.1101/2020.09.24.20200048

• A genetics-led approach defines the drug target landscape of 30 immune-related traits

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-019-0456-1

• Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

  bioRxiv (Cold Spring Harbor Laboratory) · 2018 · https://doi.org/10.1101/447367

• Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study

  The Lancet Respiratory Medicine · 2017 · 10.1016/s2213-2600(17)30294-1

• Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

  Nature Genetics · 2015 · https://doi.org/10.1038/ng.3304

• Major Histocompatibility Complex Genomics and Human Disease

  Annual Review of Genomics and Human Genetics · 2013 · https://doi.org/10.1146/annurev-genom-091212-153455

Current projects

No projects listed.