Kari Alitalo

Research interests

Publications

• A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

  The Journal of Experimental Medicine · 2015 · https://doi.org/10.1084/jem.20142290

• The lymphatic vasculature in disease

  Nature Medicine · 2011 · 10.1038/nm.2545

• Copy number variation and selection during reprogramming to pluripotency

  Nature · 2011 · https://doi.org/10.1038/nature09871

• Lymphangiogenesis: Molecular Mechanisms and Future Promise

  Cell · 2010 · 10.1016/j.cell.2010.01.045

• Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

  Nature Reviews Molecular Cell Biology · 2009 · https://doi.org/10.1038/nrm2639

• Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

  Nature Medicine · 2009 · https://doi.org/10.1038/nm.1960

• Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

  Nature · 2008 · https://doi.org/10.1038/nature07083

• Molecular regulation of angiogenesis and lymphangiogenesis

  Nature Reviews Molecular Cell Biology · 2007 · https://doi.org/10.1038/nrm2183

• Lymphangiogenesis in development and human disease

  Nature · 2005 · 10.1038/nature04480

• The biology of vascular endothelial growth factors

  Cardiovascular Research · 2005 · 10.1016/j.cardiores.2004.12.002

• VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

  The Journal of Cell Biology · 2003 · https://doi.org/10.1083/jcb.200302047

• Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

  Nature Immunology · 2003 · 10.1038/ni1013

• Lymphangiogenesis and cancer metastasis

  Nature reviews. Cancer · 2002 · 10.1038/nrc863

• Tumor-Associated Macrophages Express Lymphatic Endothelial Growth Factors and Are Related to Peritumoral Lymphangiogenesis

  American Journal Of Pathology · 2002 · 10.1016/s0002-9440(10)64255-1

• Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3

  Nature Medicine · 2001 · 10.1038/84651

• Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis

  Nature Medicine · 2001 · https://doi.org/10.1038/84643

• Clinical applications of angiogenic growth factors and their inhibitors

  Nature Medicine · 1999 · 10.1038/70928

• Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries

  American Journal Of Pathology · 1999 · 10.1016/s0002-9440(10)65285-6

• Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

  Proceedings of the National Academy of Sciences · 1998 · 10.1073/pnas.95.2.548

• Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3

  Science · 1998 · 10.1126/science.282.5390.946

• Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

  Science · 1997 · 10.1126/science.276.5317.1423

• A novel vascular endothelial growth factor, VEGF‐C, is a ligand for the Flt4 (VEGFR‐3) and KDR (VEGFR‐2) receptor tyrosine kinases.

  The EMBO Journal · 1996 · https://doi.org/10.1002/j.1460-2075.1996.tb00359.x

• Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

  Proceedings of the National Academy of Sciences · 1996 · 10.1073/pnas.93.6.2576

• Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

  Proceedings of the National Academy of Sciences · 1995 · 10.1073/pnas.92.8.3566

• Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

  Nature · 1983 · 10.1038/305245a0

Current projects

No projects listed.