John N. Weinstein

Research interests

Publications

• Comprehensive molecular characterization of mitochondrial genomes in human cancers

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0557-x

• A Consensus Molecular Classification of Muscle-invasive Bladder Cancer

  European Urology · 2019 · 10.1016/j.eururo.2019.09.006

• Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

  Cancer Cell · 2018 · https://doi.org/10.1016/j.ccell.2018.03.010

• Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.07.036

• An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.02.052

• The Immune Landscape of Cancer

  Immunity · 2018 · https://doi.org/10.1016/j.immuni.2018.03.023

• Comprehensive Characterization of Cancer Driver Genes and Mutations

  Cell · 2018 · 10.1016/j.cell.2018.02.060

• Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.03.022

• Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

  Cell · 2018 · 10.1016/j.cell.2018.03.034

• Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

  Cell · 2018 · 10.1016/j.cell.2018.03.034

• Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

  Cell Reports · 2018 · 10.1016/j.celrep.2018.03.076

• Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

  Cell Reports · 2018 · 10.1016/j.celrep.2018.03.076

• Genomic and Functional Approaches to Understanding Cancer Aneuploidy

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.03.007

• Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

  Cell Reports · 2018 · 10.1016/j.celrep.2018.03.086

• Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.07.001

• Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

  Cell Systems · 2018 · 10.1016/j.cels.2018.03.002

• Pathogenic Germline Variants in 10,389 Adult Cancers

  Cell · 2018 · 10.1016/j.cell.2018.03.039

• The chromatin accessibility landscape of primary human cancers

  Science · 2018 · 10.1126/science.aav1898

• Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

  Cell Reports · 2018 · 10.1016/j.celrep.2018.03.050

• Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

  Cell Reports · 2018 · 10.1016/j.celrep.2018.10.001

• lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.03.006

• Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

  Cell Reports · 2018 · 10.1016/j.celrep.2018.01.088

• Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma

  Cancer Cell · 2017 · 10.1016/j.ccell.2017.07.007

• Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

  Nature Genetics · 2016 · 10.1038/ng.3564

• A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition

  Clinical Cancer Research · 2015 · 10.1158/1078-0432.ccr-15-0876

• Co-occurring Genomic Alterations Define Major Subsets of KRAS -Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities

  Cancer Discovery · 2015 · 10.1158/2159-8290.cd-14-1236

• Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

  Cell · 2014 · 10.1016/j.cell.2014.06.049

• A pan-cancer proteomic perspective on The Cancer Genome Atlas

  Nature Communications · 2014 · 10.1038/ncomms4887

• Comprehensive molecular characterization of urothelial bladder carcinoma

  Nature · 2014 · 10.1038/nature12965

• The Cancer Genome Atlas Pan-Cancer analysis project

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2764

• The Somatic Genomic Landscape of Glioblastoma

  Cell · 2013 · https://doi.org/10.1016/j.cell.2013.09.034

• Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

  Journal of Clinical Investigation · 2012 · 10.1172/jci65833

• Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1

  Cancer Discovery · 2012 · 10.1158/2159-8290.cd-12-0112

• An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

  Clinical Cancer Research · 2012 · 10.1158/1078-0432.ccr-12-1558

• Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

  Science · 2011 · 10.1126/science.1206923

• Integrated genomic analyses of ovarian carcinoma

  Nature · 2011 · https://doi.org/10.1038/nature10166

• Biomarkers in Cancer Staging, Prognosis and Treatment Selection

  Nature reviews. Cancer · 2005 · 10.1038/nrc1739

• GoMiner: a resource for biological interpretation of genomic and proteomic data

  Genome biology · 2003 · 10.1186/gb-2003-4-4-r28

• A gene expression database for the molecular pharmacology of cancer

  Nature Genetics · 2000 · 10.1038/73439

• Systematic variation in gene expression patterns in human cancer cell lines

  Nature Genetics · 2000 · 10.1038/73432

• An Information-Intensive Approach to the Molecular Pharmacology of Cancer

  Science · 1997 · 10.1126/science.275.5298.343

Current projects

No projects listed.