Eyal Gottlieb

Research interests

Publications

• The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-020-00753-3

• Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

  Cell Death and Differentiation · 2018 · https://doi.org/10.1038/s41418-017-0012-4

• Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

  Nature · 2016 · https://doi.org/10.1038/nature19353

• Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.08.064

• Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

  Cancer Cell · 2015 · https://doi.org/10.1016/j.ccell.2014.12.002

• A roadmap for interpreting 13C metabolite labeling patterns from cells

  Current Opinion in Biotechnology · 2015 · https://doi.org/10.1016/j.copbio.2015.02.003

• Succinate is an inflammatory signal that induces IL-1β through HIF-1α

  Nature · 2013 · https://doi.org/10.1038/nature11986

• mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

  Cell Metabolism · 2013 · 10.1016/j.cmet.2013.10.001

• p53 status determines the role of autophagy in pancreatic tumour development

  Nature · 2013 · https://doi.org/10.1038/nature12865

• Serine is a natural ligand and allosteric activator of pyruvate kinase M2

  Nature · 2012 · https://doi.org/10.1038/nature11540

• Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

  Nature · 2012 · https://doi.org/10.1038/nature11743

• Glutaminolysis Activates Rag-mTORC1 Signaling

  Molecular Cell · 2012 · https://doi.org/10.1016/j.molcel.2012.05.043

• Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

  Nature · 2011 · https://doi.org/10.1038/nature10363

• Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

  Cell Death and Differentiation · 2011 · 10.1038/cdd.2011.96

• Genome-Scale Metabolic Modeling Elucidates the Role of Proliferative Adaptation in Causing the Warburg Effect

  PLoS Computational Biology · 2011 · https://doi.org/10.1371/journal.pcbi.1002018

• Targeting metabolic transformation for cancer therapy

  Nature reviews. Cancer · 2010 · https://doi.org/10.1038/nrc2817

• TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

  Cell · 2006 · https://doi.org/10.1016/j.cell.2006.05.036

• Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer

  Oncogene · 2006 · https://doi.org/10.1038/sj.onc.1209594

• Mitochondrial tumour suppressors: a genetic and biochemical update

  Nature reviews. Cancer · 2005 · https://doi.org/10.1038/nrc1737

• Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

  Cancer Cell · 2005 · 10.1016/j.ccr.2004.11.022

• Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis

  Cell Death and Differentiation · 2003 · https://doi.org/10.1038/sj.cdd.4401231

Current projects

No projects listed.