P. Andrew Futreal

Research interests

Publications

• Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial

  Nature Medicine · 2021 · 10.1038/s41591-020-01224-2

• Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

  Science · 2021 · 10.1126/science.aaz7015

• Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance

  Science Translational Medicine · 2017 · https://doi.org/10.1126/scitranslmed.aah3560

• AACR Project GENIE: Powering Precision Medicine through an International Consortium

  Cancer Discovery · 2017 · https://doi.org/10.1158/2159-8290.cd-17-0151

• Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

  Science · 2017 · https://doi.org/10.1126/science.aan4236

• Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.08.069

• Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

  Cancer Discovery · 2016 · https://doi.org/10.1158/2159-8290.cd-15-1545

• Landscape of somatic mutations in 560 breast cancer whole-genome sequences

  Nature · 2016 · 10.1038/nature17676

• Co-occurring Genomic Alterations Define Major Subsets of KRAS -Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities

  Cancer Discovery · 2015 · 10.1158/2159-8290.cd-14-1236

• Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

  Nature Communications · 2014 · 10.1038/ncomms3997

• Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

  Nature Genetics · 2014 · 10.1038/ng.2891

• Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

  Science · 2014 · 10.1126/science.1256930

• Signatures of mutational processes in human cancer

  Nature · 2013 · https://doi.org/10.1038/nature12477

• Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

  Nature Genetics · 2013 · 10.1038/ng.2814

• The Life History of 21 Breast Cancers

  Cell · 2012 · 10.1016/j.cell.2012.04.023

• Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

  New England Journal of Medicine · 2012 · https://doi.org/10.1056/nejmoa1113205

• Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

  Nucleic Acids Research · 2012 · 10.1093/nar/gks1111

• Systematic identification of genomic markers of drug sensitivity in cancer cells

  Nature · 2012 · 10.1038/nature11005

• Mutational Processes Molding the Genomes of 21 Breast Cancers

  Cell · 2012 · 10.1016/j.cell.2012.04.024

• The landscape of cancer genes and mutational processes in breast cancer

  Nature · 2012 · 10.1038/nature11017

• Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

  Nature · 2011 · 10.1038/nature10113

• Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

  Nature · 2011 · 10.1038/nature09639

• Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

  Cell · 2011 · 10.1016/j.cell.2010.11.055

• SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts

  New England Journal of Medicine · 2011 · 10.1056/nejmoa1103283

• The patterns and dynamics of genomic instability in metastatic pancreatic cancer

  Nature · 2010 · 10.1038/nature09460

• International network of cancer genome projects

  Nature · 2010 · 10.1038/nature08987

• COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

  Nucleic Acids Research · 2010 · 10.1093/nar/gkq929

• Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

  Nature · 2010 · 10.1038/nature08672

• A small-cell lung cancer genome with complex signatures of tobacco exposure

  Nature · 2009 · 10.1038/nature08629

• A comprehensive catalogue of somatic mutations from a human cancer genome

  Nature · 2009 · 10.1038/nature08658

• Complex landscapes of somatic rearrangement in human breast cancer genomes

  Nature · 2009 · 10.1038/nature08645

• The cancer genome

  Nature · 2009 · 10.1038/nature07943

• JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis

  New England Journal of Medicine · 2007 · 10.1056/nejmoa065202

• Patterns of somatic mutation in human cancer genomes

  Nature · 2007 · 10.1038/nature05610

• A census of human cancer genes

  Nature reviews. Cancer · 2004 · 10.1038/nrc1299

• Intragenic ERBB2 kinase mutations in tumours

  Nature · 2004 · 10.1038/431525b

• BRAF and RAS mutations in human lung cancer and melanoma.

  PubMed · 2002

• Mutations of the BRAF gene in human cancer

  Nature · 2002 · https://doi.org/10.1038/nature00766

• Identification of the breast cancer susceptibility gene BRCA2

  Nature · 1995 · 10.1038/378789a0

• A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

  Science · 1994 · https://doi.org/10.1126/science.7545954

Current projects

No projects listed.