Mien‐Chie Hung

Research interests

Publications

• PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

  Nature Cell Biology · 2020 · https://doi.org/10.1038/s41556-020-0575-z

• Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy

  Cancer Cell · 2019 · 10.1016/j.ccell.2019.06.008

• Mechanisms Controlling PD-L1 Expression in Cancer

  Molecular Cell · 2019 · 10.1016/j.molcel.2019.09.030

• Long noncoding RNA MALAT1 suppresses breast cancer metastasis

  Nature Genetics · 2018 · 10.1038/s41588-018-0252-3

• BAP1 links metabolic regulation of ferroptosis to tumour suppression

  Nature Cell Biology · 2018 · https://doi.org/10.1038/s41556-018-0178-0

• Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

  Molecular Cell · 2018 · 10.1016/j.molcel.2018.07.030

• PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression

  Clinical Cancer Research · 2017 · 10.1158/1078-0432.ccr-16-3215

• Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms12632

• Deubiquitination and Stabilization of PD-L1 by CSN5

  Cancer Cell · 2016 · 10.1016/j.ccell.2016.10.010

• Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

  Cancer Cell · 2013 · 10.1016/j.ccr.2013.01.022

• p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

  Nature Cell Biology · 2011 · 10.1038/ncb2173

• Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer

  Journal of Clinical Oncology · 2009 · 10.1200/jco.2009.19.6410

• ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

  Nature Cell Biology · 2008 · 10.1038/ncb1676

• An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer

  Cancer Research · 2008 · https://doi.org/10.1158/0008-5472.can-07-6854

• Mechanisms of Disease: understanding resistance to HER2-targeted therapy in human breast cancer

  Nature Clinical Practice Oncology · 2006 · 10.1038/ncponc0509

• Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition

  Nature Cell Biology · 2004 · https://doi.org/10.1038/ncb1173

• PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients

  Cancer Cell · 2004 · 10.1016/j.ccr.2004.06.022

• IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a

  Cell · 2004 · 10.1016/s0092-8674(04)00302-2

• Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

  Nature Cell Biology · 2001 · 10.1038/35060032

• HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

  Nature Cell Biology · 2001 · 10.1038/ncb1101-973

• Nuclear localization of EGF receptor and its potential new role as a transcription factor

  Nature Cell Biology · 2001 · 10.1038/ncb0901-802

• β-Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression

  Proceedings of the National Academy of Sciences · 2000 · 10.1073/pnas.060025397

• Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors.

  PubMed · 1997

• Requirement for neuregulin receptor erbB2 in neural and cardiac development

  Nature · 1995 · 10.1038/378394a0

• Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

  Cell · 1986 · 10.1016/0092-8674(86)90779-8

• The neu oncogene encodes an epidermal growth factor receptor-related protein

  Nature · 1986 · 10.1038/319226a0

Current projects

No projects listed.