Ken Chen

Research interests

Publications

• Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes

  Nature Biotechnology · 2021 · 10.1038/s41587-020-00795-2

• Patterns of somatic structural variation in human cancer genomes

  Nature · 2020 · https://doi.org/10.1038/s41586-019-1913-9

• Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0562-0

• Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0576-7

• Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-019-0564-y

• Integrative pathway enrichment analysis of multivariate omics data

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-13983-9

• Genomic footprints of activated telomere maintenance mechanisms in cancer

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-13824-9

• The Immune Landscape of Cancer

  Immunity · 2019 · https://doi.org/10.1016/j.immuni.2019.08.004

• Multi-platform discovery of haplotype-resolved structural variation in human genomes

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-018-08148-z

• An integrated map of structural variation in 2,504 human genomes

  Nature · 2015 · 10.1038/nature15394

• Clonal evolution in breast cancer revealed by single nucleus genome sequencing

  Nature · 2014 · 10.1038/nature13600

• Clonal Architecture of Secondary Acute Myeloid Leukemia

  New England Journal of Medicine · 2012 · 10.1056/nejmoa1106968

• Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

  Nature · 2012 · 10.1038/nature10738

• The Origin and Evolution of Mutations in Acute Myeloid Leukemia

  Cell · 2012 · 10.1016/j.cell.2012.06.023

• Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

  Cell · 2012 · 10.1016/j.cell.2012.08.024

• Whole-genome analysis informs breast cancer response to aromatase inhibition

  Nature · 2012 · 10.1038/nature11143

• SomaticSniper: identification of somatic point mutations in whole genome sequencing data

  Bioinformatics · 2011 · 10.1093/bioinformatics/btr665

• Mapping copy number variation by population-scale genome sequencing

  Nature · 2011 · 10.1038/nature09708

• Genome remodelling in a basal-like breast cancer metastasis and xenograft

  Nature · 2010 · 10.1038/nature08989

• BreakDancer: an algorithm for high-resolution mapping of genomic structural variation

  Nature Methods · 2009 · 10.1038/nmeth.1363

• VarScan: variant detection in massively parallel sequencing of individual and pooled samples

  Bioinformatics · 2009 · 10.1093/bioinformatics/btp373

• Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

  New England Journal of Medicine · 2009 · 10.1056/nejmoa0903840

• Comprehensive genomic characterization defines human glioblastoma genes and core pathways

  Nature · 2008 · 10.1038/nature07385

• Somatic mutations affect key pathways in lung adenocarcinoma

  Nature · 2008 · 10.1038/nature07423

• DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

  Nature · 2008 · 10.1038/nature07485

• The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

  Cell · 1998 · 10.1016/s0092-8674(00)81400-2

Current projects

No projects listed.