Weiya Xia

Research interests

Publications

• PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

  Nature Cell Biology · 2020 · https://doi.org/10.1038/s41556-020-0575-z

• Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy

  Cancer Cell · 2019 · 10.1016/j.ccell.2019.06.008

• STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-04313-6

• Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

  Molecular Cell · 2018 · 10.1016/j.molcel.2018.07.030

• Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.01.009

• Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth

  Cell Research · 2018 · https://doi.org/10.1038/s41422-018-0060-4

• PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression

  Clinical Cancer Research · 2017 · 10.1158/1078-0432.ccr-16-3215

• Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms12632

• Deubiquitination and Stabilization of PD-L1 by CSN5

  Cancer Cell · 2016 · 10.1016/j.ccell.2016.10.010

• Epithelial–Mesenchymal Transition Induced by TNF-α Requires NF-κB–Mediated Transcriptional Upregulation of Twist1

  Cancer Research · 2012 · https://doi.org/10.1158/0008-5472.can-11-3123

• p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

  Nature Cell Biology · 2011 · 10.1038/ncb2173

• TRIM24 links a non-canonical histone signature to breast cancer

  Nature · 2010 · https://doi.org/10.1038/nature09542

• ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

  Nature Cell Biology · 2008 · 10.1038/ncb1676

• Epidermal Growth Factor Receptor Cooperates with Signal Transducer and Activator of Transcription 3 to Induce Epithelial-Mesenchymal Transition in Cancer Cells via Up-regulation of TWIST Gene Expression

  Cancer Research · 2007 · 10.1158/0008-5472.can-07-0575

• Degradation of Mcl-1 by β-TrCP Mediates Glycogen Synthase Kinase 3-Induced Tumor Suppression and Chemosensitization

  Molecular and Cellular Biology · 2007 · https://doi.org/10.1128/mcb.00620-06

• Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin

  Molecular Cell · 2005 · 10.1016/j.molcel.2005.06.009

• Akt-Mediated Phosphorylation of EZH2 Suppresses Methylation of Lysine 27 in Histone H3

  Science · 2005 · 10.1126/science.1118947

• Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

  Cancer Cell · 2005 · 10.1016/j.ccr.2005.05.007

• Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition

  Nature Cell Biology · 2004 · https://doi.org/10.1038/ncb1173

• Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis

  Cancer Cell · 2004 · 10.1016/j.ccr.2004.09.027

• IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a

  Cell · 2004 · 10.1016/s0092-8674(04)00302-2

• Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

  Nature Cell Biology · 2001 · https://doi.org/10.1038/35060032

• HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

  Nature Cell Biology · 2001 · 10.1038/ncb1101-973

• Nuclear localization of EGF receptor and its potential new role as a transcription factor

  Nature Cell Biology · 2001 · https://doi.org/10.1038/ncb0901-802

• β-Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression

  Proceedings of the National Academy of Sciences · 2000 · 10.1073/pnas.060025397

Current projects

No projects listed.