Chuan He

Research interests

Publications

• Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

  Molecular Cell · 2019 · 10.1016/j.molcel.2019.04.025

• Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

  Nature Cell Biology · 2018 · 10.1038/s41556-018-0045-z

• RNA modifications modulate gene expression during development

  Science · 2018 · 10.1126/science.aau1646

• m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

  Nature Cell Biology · 2018 · https://doi.org/10.1038/s41556-018-0174-4

• VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

  Cell Discovery · 2018 · https://doi.org/10.1038/s41421-018-0019-0

• Dynamic RNA Modifications in Gene Expression Regulation

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.05.045

• YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA

  Cell Research · 2017 · 10.1038/cr.2017.15

• m 6 A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program

  Cancer Cell · 2017 · 10.1016/j.ccell.2017.02.013

• m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

  Cell Reports · 2017 · 10.1016/j.celrep.2017.02.059

• YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

  eLife · 2017 · 10.7554/elife.31311

• R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

  Cell · 2017 · 10.1016/j.cell.2017.11.031

• FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N 6 -Methyladenosine RNA Demethylase

  Cancer Cell · 2016 · 10.1016/j.ccell.2016.11.017

• Post-transcriptional gene regulation by mRNA modifications

  Nature Reviews Molecular Cell Biology · 2016 · 10.1038/nrm.2016.132

• The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA

  Nature · 2016 · https://doi.org/10.1038/nature16998

• RNA N 6 -methyladenosine methylation in post-transcriptional gene expression regulation

  Genes & Development · 2015 · https://doi.org/10.1101/gad.262766.115

• N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

  Nature · 2015 · 10.1038/nature14234

• N6-methyladenosine Modulates Messenger RNA Translation Efficiency

  Cell · 2015 · 10.1016/j.cell.2015.05.014

• Gene expression regulation mediated through reversible m6A RNA methylation

  Nature Reviews Genetics · 2014 · 10.1038/nrg3724

• FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

  Cell Research · 2014 · 10.1038/cr.2014.151

• N6-methyladenosine-dependent regulation of messenger RNA stability

  Nature · 2013 · 10.1038/nature12730

• Global Epigenomic Reconfiguration During Mammalian Brain Development

  Science · 2013 · 10.1126/science.1237905

• A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

  Nature Chemical Biology · 2013 · 10.1038/nchembio.1432

• ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

  Molecular Cell · 2012 · 10.1016/j.molcel.2012.10.015

• Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome

  Cell · 2012 · 10.1016/j.cell.2012.04.027

• N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

  Nature Chemical Biology · 2011 · 10.1038/nchembio.687

• Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

  Science · 2011 · 10.1126/science.1210944

• Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

  Science · 2011 · 10.1126/science.1210597

• Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

  Cancer Cell · 2011 · 10.1016/j.ccr.2011.06.001

• Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

  Nature Biotechnology · 2010 · 10.1038/nbt.1732

Current projects

No projects listed.