Zhijian J. Chen

Research interests

Publications

• Structural basis of STING binding with and phosphorylation by TBK1

  Nature · 2019 · 10.1038/s41586-019-1000-2

• cGAS in action: Expanding roles in immunity and inflammation

  Science · 2019 · 10.1126/science.aat8657

• Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

  Nature · 2019 · 10.1038/s41586-019-1006-9

• DNA-induced liquid phase condensation of cGAS activates innate immune signaling

  Science · 2018 · 10.1126/science.aat1022

• The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

  The Journal of Experimental Medicine · 2018 · 10.1084/jem.20180139

• cGAS is essential for cellular senescence

  Proceedings of the National Academy of Sciences · 2017 · 10.1073/pnas.1705499114

• Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

  Nature Immunology · 2016 · https://doi.org/10.1038/ni.3558

• Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

  Science · 2015 · 10.1126/science.aaa2630

• The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

  Molecular Cell · 2014 · 10.1016/j.molcel.2014.03.040

• Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

  Cell · 2014 · https://doi.org/10.1016/j.cell.2014.11.037

• Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

  Annual Review of Immunology · 2014 · 10.1146/annurev-immunol-032713-120156

• STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

  Immunity · 2014 · https://doi.org/10.1016/j.immuni.2014.10.019

• Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

  Science · 2013 · 10.1126/science.1240933

• Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

  Molecular Cell · 2013 · 10.1016/j.molcel.2013.05.022

• Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

  Science · 2013 · 10.1126/science.1244040

• STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

  Science Signaling · 2012 · 10.1126/scisignal.2002521

• Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

  Science · 2012 · https://doi.org/10.1126/science.1229963

• Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

  Science · 2012 · https://doi.org/10.1126/science.1232458

• MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

  Cell · 2011 · 10.1016/j.cell.2011.06.041

• RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

  Cell · 2009 · 10.1016/j.cell.2009.06.015

• TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

  Nature · 2007 · 10.1038/nature05732

• Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

  Cell · 2005 · 10.1016/j.cell.2005.08.012

• Ubiquitin signalling in the NF-κB pathway

  Nature Cell Biology · 2005 · 10.1038/ncb0805-758

• The DNA sequence of the human X chromosome

  Nature · 2005 · 10.1038/nature03440

• TAK1 is a ubiquitin-dependent kinase of MKK and IKK

  Nature · 2001 · 10.1038/35085597

• Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

  Cell · 2000 · 10.1016/s0092-8674(00)00126-4

Current projects

No projects listed.