Kevan M. Shokat

Research interests

Publications

• A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

  bioRxiv (Cold Spring Harbor Laboratory) · 2020 · https://doi.org/10.1101/2020.03.22.002386

• The Global Phosphorylation Landscape of SARS-CoV-2 Infection

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.06.034

• Drugging the 'undruggable' cancer targets

  Nature reviews. Cancer · 2017 · https://doi.org/10.1038/nrc.2017.36

• Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

  Nature Reviews Drug Discovery · 2016 · https://doi.org/10.1038/nrd.2016.139

• N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.03.001

• Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

  Nature · 2016 · https://doi.org/10.1038/nature17963

• K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

  Nature · 2013 · https://doi.org/10.1038/nature12796

• The translational landscape of mTOR signalling steers cancer initiation and metastasis

  Nature · 2012 · https://doi.org/10.1038/nature10912

• Targeting the cancer kinome through polypharmacology

  Nature reviews. Cancer · 2010 · https://doi.org/10.1038/nrc2787

• RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

  Nature · 2010 · https://doi.org/10.1038/nature08902

• Rewiring of Genetic Networks in Response to DNA Damage

  Science · 2010 · https://doi.org/10.1126/science.1195618

• Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

  Cancer Cell · 2010 · https://doi.org/10.1016/j.ccr.2010.01.021

• Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

  PLoS Biology · 2009 · https://doi.org/10.1371/journal.pbio.1000038

• T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

  Proceedings of the National Academy of Sciences · 2008 · https://doi.org/10.1073/pnas.0800928105

• Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

  Nature Chemical Biology · 2008 · https://doi.org/10.1038/nchembio.117

• The unfolded protein response signals through high-order assembly of Ire1

  Nature · 2008 · https://doi.org/10.1038/nature07661

• The Site-Specific Installation of Methyl-Lysine Analogs into Recombinant Histones

  Cell · 2007 · https://doi.org/10.1016/j.cell.2006.12.041

• IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response

  Science · 2007 · https://doi.org/10.1126/science.1146361

• Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3

  Nature · 2007 · https://doi.org/10.1038/nature05474

• A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

  Cell · 2006 · https://doi.org/10.1016/j.cell.2006.03.035

• A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

  Cancer Cell · 2006 · https://doi.org/10.1016/j.ccr.2006.03.029

• Features of Selective Kinase Inhibitors

  Chemistry & Biology · 2005 · https://doi.org/10.1016/j.chembiol.2005.04.011

• Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors

  Science · 2005 · https://doi.org/10.1126/science1108367

• Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

  Proceedings of the National Academy of Sciences · 1997 · https://doi.org/10.1073/pnas.94.8.3565

Current projects

No projects listed.