Els Pardon

Research interests

Publications

• The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

  Cell · 2019 · 10.1016/j.cell.2018.11.025

• GABAA receptor signalling mechanisms revealed by structural pharmacology.

  PubMed · 2019 · 10.1038/s41586-018-0832-5

• Structures of influenza A virus RNA polymerase offer insight into viral genome replication

  Nature · 2019 · 10.1038/s41586-019-1530-7

• Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

  Cell · 2018 · 10.1016/j.cell.2017.12.011

• Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer

  Nature · 2018 · 10.1038/s41586-018-0833-4

• Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling

  Nature · 2018 · 10.1038/nature25010

• Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

  Nature Chemical Biology · 2018 · 10.1038/s41589-018-0145-x

• GABAA receptor signalling mechanisms revealed by structural pharmacology

  Nature · 2018 · 10.1038/s41586-018-0832-5

• Structural basis for GABAA receptor potentiation by neurosteroids

  Nature Structural & Molecular Biology · 2017 · 10.1038/nsmb.3484

• Structure of PINK1 in complex with its substrate ubiquitin

  Nature · 2017 · 10.1038/nature24645

• Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

  Nature · 2016 · 10.1038/nature18636

• Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

  Nature · 2016 · 10.1038/nature18324

• Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family

  Nature Structural & Molecular Biology · 2015 · 10.1038/nsmb.3091

• Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

  Science · 2015 · 10.1126/science.aac7365

• Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport

  Nature Structural & Molecular Biology · 2014 · 10.1038/nsmb.2904

• A general protocol for the generation of Nanobodies for structural biology

  Nature Protocols · 2014 · https://doi.org/10.1038/nprot.2014.039

• Activation and allosteric modulation of a muscarinic acetylcholine receptor

  Nature · 2013 · https://doi.org/10.1038/nature12735

• Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1309275110

• Structure of a nanobody-stabilized active state of the β2 adrenoceptor

  Nature · 2011 · https://doi.org/10.1038/nature09648

• Crystal structure of the β2 adrenergic receptor–Gs protein complex

  Nature · 2011 · https://doi.org/10.1038/nature10361

• Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex

  Proceedings of the National Academy of Sciences · 2011 · 10.1073/pnas.1113645108

• Structure and Properties of a Complex of α-Synuclein and a Single-Domain Camelid Antibody

  Journal of Molecular Biology · 2010 · 10.1016/j.jmb.2010.07.001

• Crystal Structure of the N-Terminal Domain of the Secretin GspD from ETEC Determined with the Assistance of a Nanobody

  Structure · 2009 · 10.1016/j.str.2008.11.011

• Identification of a Universal VHH Framework to Graft Non-canonical Antigen-binding Loops of Camel Single-domain Antibodies

  Journal of Molecular Biology · 2005 · 10.1016/j.jmb.2005.07.038

• Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13 in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome)

  Nature Genetics · 1997 · 10.1038/ng0597-88

Current projects

No projects listed.