Eicke Latz

Research interests

Publications

• Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

  Cellular and Molecular Immunology · 2021 · 10.1038/s41423-020-00630-3

• Trained immunity, tolerance, priming and differentiation: distinct immunological processes

  Nature Immunology · 2020 · https://doi.org/10.1038/s41590-020-00845-6

• Defining trained immunity and its role in health and disease

  Nature reviews. Immunology · 2020 · https://doi.org/10.1038/s41577-020-0285-6

• NLRP3 inflammasome activation drives tau pathology

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1769-z

• Targeting the NLRP3 inflammasome in inflammatory diseases

  Nature Reviews Drug Discovery · 2018 · 10.1038/nrd.2018.97

• Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

  Cell · 2018 · https://doi.org/10.1016/j.cell.2017.12.013

• Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

  Nature · 2017 · https://doi.org/10.1038/nature25158

• A guiding map for inflammation

  Nature Immunology · 2017 · 10.1038/ni.3790

• Trained immunity: A program of innate immune memory in health and disease

  Science · 2016 · 10.1126/science.aaf1098

• Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

  Cell · 2015 · 10.1016/j.cell.2015.10.048

• Neuroinflammation in Alzheimer's disease

  The Lancet Neurology · 2015 · https://doi.org/10.1016/s1474-4422(15)70016-5

• A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

  Nature Medicine · 2015 · 10.1038/nm.3806

• Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

  Immunity · 2014 · 10.1016/j.immuni.2014.01.006

• Innate immune activation in neurodegenerative disease

  Nature reviews. Immunology · 2014 · 10.1038/nri3705

• Activation and regulation of the inflammasomes

  Nature reviews. Immunology · 2013 · 10.1038/nri3452

• NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

  Nature · 2012 · https://doi.org/10.1038/nature11729

• NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

  Nature · 2010 · https://doi.org/10.1038/nature08938

• IFI16 is an innate immune sensor for intracellular DNA

  Nature Immunology · 2010 · 10.1038/ni.1932

• The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

  Nature Immunology · 2010 · 10.1038/ni.1864

• AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

  Nature · 2009 · 10.1038/nature07725

• Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

  The Journal of Immunology · 2009 · https://doi.org/10.4049/jimmunol.0901363

• Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

  Nature Immunology · 2008 · https://doi.org/10.1038/ni.1631

• The NALP3 inflammasome is involved in the innate immune response to amyloid-β

  Nature Immunology · 2008 · 10.1038/ni.1636

• Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

  Nature Immunology · 2007 · 10.1038/ni1457

• TLR9 signals after translocating from the ER to CpG DNA in the lysosome

  Nature Immunology · 2004 · 10.1038/ni1028

• IKKε and TBK1 are essential components of the IRF3 signaling pathway

  Nature Immunology · 2003 · 10.1038/ni921

• LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

  The Journal of Experimental Medicine · 2003 · 10.1084/jem.20031023

Current projects

No projects listed.