Himisha Beltran

Research interests

Publications

• Management of Patients with Advanced Prostate Cancer. Report from the 2024 Advanced Prostate Cancer Consensus Conference (APCCC)

  European Urology · 2024 · https://doi.org/10.1016/j.eururo.2024.09.017

• Management of patients with advanced prostate cancer—metastatic and/or castration-resistant prostate cancer: Report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022

  European Journal of Cancer · 2023 · https://doi.org/10.1016/j.ejca.2023.02.018

• Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer

  Journal of Clinical Investigation · 2020 · https://doi.org/10.1172/jci131041

• Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019

  Journal of Clinical Oncology · 2020 · https://doi.org/10.1200/jco.20.00046

• Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline

  Journal of Clinical Oncology · 2019 · https://doi.org/10.1200/jco.19.02768

• Genomic correlates of clinical outcome in advanced prostate cancer

  Proceedings of the National Academy of Sciences · 2019 · https://doi.org/10.1073/pnas.1902651116

• Clinical features of neuroendocrine prostate cancer

  European Journal of Cancer · 2019 · https://doi.org/10.1016/j.ejca.2019.08.011

• Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer

  Science Translational Medicine · 2019 · https://doi.org/10.1126/scitranslmed.aav0891

• Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-10873-y

• Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study

  Journal of Clinical Oncology · 2018 · https://doi.org/10.1200/jco.2017.77.6880

• The long tail of oncogenic drivers in prostate cancer

  Nature Genetics · 2018 · https://doi.org/10.1038/s41588-018-0078-z

• Patient derived organoids to model rare prostate cancer phenotypes

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-04495-z

• A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers

  Clinical Cancer Research · 2018 · https://doi.org/10.1158/1078-0432.ccr-18-1912

• Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017

  European Urology · 2017 · https://doi.org/10.1016/j.eururo.2017.06.002

• SOX2 promotes lineage plasticity and antiandrogen resistance in TP53 - and RB1 -deficient prostate cancer

  Science · 2017 · 10.1126/science.aah4307

• Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

  Cancer Discovery · 2017 · https://doi.org/10.1158/2159-8290.cd-16-1154

• Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

  New England Journal of Medicine · 2016 · 10.1056/nejmoa1603144

• Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer

  Nature Medicine · 2016 · 10.1038/nm.4045

• Clonal evolution of chemotherapy-resistant urothelial carcinoma

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3692

• Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response

  JAMA Oncology · 2015 · https://doi.org/10.1001/jamaoncol.2015.1313

• Integrative Clinical Genomics of Advanced Prostate Cancer

  Cell · 2015 · 10.1016/j.cell.2015.05.001

• Organoid Cultures Derived from Patients with Advanced Prostate Cancer

  Cell · 2014 · 10.1016/j.cell.2014.08.016

• Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing

  Nature Biotechnology · 2013 · 10.1038/nbt.2696

• Punctuated Evolution of Prostate Cancer Genomes

  Cell · 2013 · 10.1016/j.cell.2013.03.021

• Concurrent AURKA and MYCN Gene Amplifications Are Harbingers of Lethal TreatmentRelated Neuroendocrine Prostate Cancer

  Neoplasia · 2013 · https://doi.org/10.1593/neo.121550

• Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity

  European Urology · 2012 · https://doi.org/10.1016/j.eururo.2012.08.053

• Challenges in Recognizing Treatment-Related Neuroendocrine Prostate Cancer

  Journal of Clinical Oncology · 2012 · https://doi.org/10.1200/jco.2011.41.5166

• From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer

  The Journal of Pathology · 2012 · https://doi.org/10.1002/path.4047

• Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets

  Cancer Discovery · 2011 · 10.1158/2159-8290.cd-11-0130

Current projects

No projects listed.