Gregory L. Verdine

Research interests

Publications

• Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

  Nature Biotechnology · 2017 · https://doi.org/10.1038/nbt.3948

• Stapled Peptides for Intracellular Drug Targets

  Methods in enzymology on CD-ROM/Methods in enzymology · 2012 · https://doi.org/10.1016/b978-0-12-396962-0.00001-x

• Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

  Nature Protocols · 2011 · https://doi.org/10.1038/nprot.2011.324

• Nonspecifically bound proteins spin while diffusing along DNA

  Nature Structural & Molecular Biology · 2009 · https://doi.org/10.1038/nsmb.1716

• Direct inhibition of the NOTCH transcription factor complex

  Nature · 2009 · https://doi.org/10.1038/nature08543

• The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members

  Clinical Cancer Research · 2007 · https://doi.org/10.1158/1078-0432.ccr-07-2184

• Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide

  Journal of the American Chemical Society · 2007 · https://doi.org/10.1021/ja0693587

• Regulation of MLL1 H3K4 methyltransferase activity by its core components

  Nature Structural & Molecular Biology · 2006 · https://doi.org/10.1038/nsmb1128

• A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA

  Proceedings of the National Academy of Sciences · 2006 · https://doi.org/10.1073/pnas.0509723103

• A Stapled BID BH3 Helix Directly Binds and Activates BAX

  Molecular Cell · 2006 · https://doi.org/10.1016/j.molcel.2006.08.020

• Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA

  Nature · 2005 · https://doi.org/10.1038/nature03458

• Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix

  Science · 2004 · https://doi.org/10.1126/science.1099191

• Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase

  Nature · 2004 · https://doi.org/10.1038/nature02306

• An All-Hydrocarbon Cross-Linking System for Enhancing the Helicity and Metabolic Stability of Peptides

  Journal of the American Chemical Society · 2000 · https://doi.org/10.1021/ja000563a

• Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA

  Nature · 2000 · https://doi.org/10.1038/35002510

• Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance

  Science · 1998 · https://doi.org/10.1126/science.282.5394.1669

• DNA (cytosine-5)-methyltransferases in mouse cells and tissues. studies with a mechanism-based probe

  Journal of Molecular Biology · 1997 · https://doi.org/10.1006/jmbi.1997.1125

• A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer

  Current Biology · 1997 · https://doi.org/10.1016/s0960-9822(06)00187-4

• Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily

  Current Biology · 1996 · https://doi.org/10.1016/s0960-9822(02)00641-3

• The crystal structure of Haelll methyltransferase covalently complexed to DNA: An extrahelical cytosine and rearranged base pairing

  Cell · 1995 · https://doi.org/10.1016/0092-8674(95)90060-8

• Structure of the NF-κB p50 homodimer bound to DNA

  Nature · 1995 · https://doi.org/10.1038/373311a0

• The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

  Nature · 1993 · https://doi.org/10.1038/365352a0

• Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp

  Science · 1993 · https://doi.org/10.1126/science.8235597

• Molecular cloning and overexpression of the human FK506-binding protein FKBP

  Nature · 1990 · 10.1038/346671a0

• Isolation and Structure of a Covalent Cross-Link Adduct Between Mitomycin C and DNA

  Science · 1987 · https://doi.org/10.1126/science.3103215

Current projects

No projects listed.