Alfred L. Goldberg

Research interests

Publications

• The Logic of the 26S Proteasome

  Cell · 2017 · 10.1016/j.cell.2017.04.023

• Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

  Nature Communications · 2015 · 10.1038/ncomms7670

• Muscle wasting in disease: molecular mechanisms and promising therapies

  Nature Reviews Drug Discovery · 2014 · 10.1038/nrd4467

• Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

  Cell · 2010 · 10.1016/j.cell.2010.07.011

• Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

  Autophagy · 2008 · https://doi.org/10.4161/auto.5338

• FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

  Cell Metabolism · 2007 · https://doi.org/10.1016/j.cmet.2007.11.001

• FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells

  Cell Metabolism · 2007 · 10.1016/j.cmet.2007.11.004

• Protein Degradation by the Ubiquitin–Proteasome Pathway in Normal and Disease States

  Journal of the American Society of Nephrology · 2006 · 10.1681/asn.2006010083

• PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

  Proceedings of the National Academy of Sciences · 2006 · https://doi.org/10.1073/pnas.0607795103

• IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1

  American Journal of Physiology-Endocrinology and Metabolism · 2004 · 10.1152/ajpendo.00073.2004

• Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

  Cell · 2004 · https://doi.org/10.1016/s0092-8674(04)00400-3

• Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

  The FASEB Journal · 2004 · 10.1096/fj.03-0610com

• Protein degradation and protection against misfolded or damaged proteins

  Nature · 2003 · https://doi.org/10.1038/nature02263

• Proteasome inhibitors: from research tools to drug candidates

  Chemistry & Biology · 2001 · 10.1016/s1074-5521(01)00056-4

• Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

  Proceedings of the National Academy of Sciences · 2001 · 10.1073/pnas.251541198

• Trehalose Accumulation during Cellular Stress Protects Cells and Cellular Proteins from Damage by Oxygen Radicals

  Journal of Biological Chemistry · 2001 · 10.1074/jbc.m101487200

• DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

  Annual Review of Immunology · 1999 · 10.1146/annurev.immunol.17.1.739

• Proteasome inhibitors: valuable new tools for cell biologists

  Trends in Cell Biology · 1998 · 10.1016/s0962-8924(98)01346-4

• Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway

  New England Journal of Medicine · 1996 · 10.1056/nejm199612193352507

• Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

  Cell · 1995 · 10.1016/0092-8674(95)90241-4

• Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

  Cell · 1994 · 10.1016/s0092-8674(94)90462-6

• Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

  Science · 1986 · 10.1126/science.3083508

• Stimulation of Muscle Protein Degradation and Prostaglandin E2Release by Leukocytic Pyrogen (Interleukin-1)

  New England Journal of Medicine · 1983 · 10.1056/nejm198303103081002

• Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm.

  Journal of Biological Chemistry · 1975 · 10.1016/s0021-9258(19)42013-9

• Intracellular Protein Degradation in Mammalian and Bacterial Cells

  Annual Review of Biochemistry · 1974 · 10.1146/annurev.bi.43.070174.004155

Current projects

No projects listed.