Bradley T. Hyman

Research interests

Publications

• Alzheimer disease

  Nature Reviews Disease Primers · 2021 · https://doi.org/10.1038/s41572-021-00269-y

• Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.10.029

• Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-14279-8

• Synergy between amyloid-β and tau in Alzheimer’s disease

  Nature Neuroscience · 2020 · 10.1038/s41593-020-0687-6

• The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

  Cell Reports · 2019 · https://doi.org/10.1016/j.celrep.2019.03.099

• Tau protein liquid–liquid phase separation can initiate tau aggregation

  The EMBO Journal · 2018 · 10.15252/embj.201798049

• Analysis of shared heritability in common disorders of the brain

  Science · 2018 · https://doi.org/10.1126/science.aap8757

• The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

  Neuron · 2014 · 10.1016/j.neuron.2014.05.004

• Primary age-related tauopathy (PART): a common pathology associated with human aging

  Acta Neuropathologica · 2014 · 10.1007/s00401-014-1349-0

• Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

  Neuron · 2012 · 10.1016/j.neuron.2011.11.033

• National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

  Alzheimer s & Dementia · 2012 · https://doi.org/10.1016/j.jalz.2011.10.007

• Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

  Journal of Neuropathology & Experimental Neurology · 2012 · 10.1097/nen.0b013e31825018f7

• National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

  Acta Neuropathologica · 2011 · https://doi.org/10.1007/s00401-011-0910-3

• Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

  Nature Genetics · 2011 · 10.1038/ng.801

• Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup

  Alzheimer s & Dementia · 2011 · 10.1016/j.jalz.2011.05.2351

• The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

  Alzheimer s & Dementia · 2011 · https://doi.org/10.1016/j.jalz.2011.03.005

• An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest

  NeuroImage · 2006 · https://doi.org/10.1016/j.neuroimage.2006.01.021

• Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

  Science · 2005 · 10.1126/science.1113694

• Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation

  Proceedings of the National Academy of Sciences · 2003 · 10.1073/pnas.0832308100

• Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

  Annals of Neurology · 1997 · 10.1002/ana.410410106

• Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease

  Journal of Neuropathology & Experimental Neurology · 1997 · 10.1097/00005072-199710000-00002

• Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

  Journal of Neuroscience · 1996 · 10.1523/jneurosci.16-14-04491.1996

• Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

  Neuron · 1993 · 10.1016/0896-6273(93)90070-8

• Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

  Neurology · 1992 · https://doi.org/10.1212/wnl.42.3.631

• The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease

  Cerebral Cortex · 1991 · 10.1093/cercor/1.1.103

• Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation

  Science · 1984 · 10.1126/science.6474172

Current projects

No projects listed.