Ralph Weissleder

Research interests

Publications

• CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers

  Science · 2023 · https://doi.org/10.1126/science.ade2292

• TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

  Nature Biomedical Engineering · 2018 · 10.1038/s41551-018-0236-8

• New Technologies for Analysis of Extracellular Vesicles

  Chemical Reviews · 2018 · 10.1021/acs.chemrev.7b00534

• Macrophages Facilitate Electrical Conduction in the Heart

  Cell · 2017 · https://doi.org/10.1016/j.cell.2017.03.050

• Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

  Immunity · 2016 · https://doi.org/10.1016/j.immuni.2015.11.024

• Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor

  Nature Biotechnology · 2014 · 10.1038/nbt.2886

• Local proliferation dominates lesional macrophage accumulation in atherosclerosis

  Nature Medicine · 2013 · https://doi.org/10.1038/nm.3258

• Myocardial infarction accelerates atherosclerosis

  Nature · 2012 · https://doi.org/10.1038/nature11260

• Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

  Cell · 2012 · 10.1016/j.cell.2012.01.058

• Epigenetic memory in induced pluripotent stem cells

  Nature · 2010 · https://doi.org/10.1038/nature09342

• Near-infrared fluorescence: application to in vivo molecular imaging

  Current Opinion in Chemical Biology · 2009 · 10.1016/j.cbpa.2009.09.029

• Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

  Science · 2009 · https://doi.org/10.1126/science.1175202

• Imaging in the era of molecular oncology

  Nature · 2008 · https://doi.org/10.1038/nature06917

• Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

  Nature Medicine · 2008 · 10.1038/nm.1890

• Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata

  Journal of Clinical Investigation · 2007 · 10.1172/jci29950

• The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

  The Journal of Experimental Medicine · 2007 · https://doi.org/10.1084/jem.20070885

• Restoration of p53 function leads to tumour regression in vivo

  Nature · 2007 · 10.1038/nature05541

• Molecular Imaging in Cancer

  Science · 2006 · 10.1126/science.1125949

• Looking and listening to light: the evolution of whole-body photonic imaging

  Nature Biotechnology · 2005 · 10.1038/nbt1074

• Shedding light onto live molecular targets

  Nature Medicine · 2003 · 10.1038/nm0103-123

• Noninvasive Detection of Clinically Occult Lymph-Node Metastases in Prostate Cancer

  New England Journal of Medicine · 2003 · 10.1056/nejmoa022749

• Molecular Imaging

  Radiology · 2001 · 10.1148/radiology.219.2.r01ma19316

• A clearer vision for in vivo imaging

  Nature Biotechnology · 2001 · https://doi.org/10.1038/86684

• Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells

  Nature Biotechnology · 2000 · 10.1038/74464

• In vivo imaging of tumors with protease-activated near-infrared fluorescent probes

  Nature Biotechnology · 1999 · 10.1038/7933

• Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging.

  Radiology · 1990 · 10.1148/radiology.175.2.2326474

• Superparamagnetic iron oxide: pharmacokinetics and toxicity

  American Journal of Roentgenology · 1989 · 10.2214/ajr.152.1.167

Current projects

No projects listed.