Chris Jones

Research interests

Publications

• Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma

  New England Journal of Medicine · 2022 · 10.1056/nejmoa2202028

• A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR

  Neuro-Oncology · 2020 · https://doi.org/10.1093/neuonc/noaa251

• Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries

  Journal of Clinical Oncology · 2018 · https://doi.org/10.1200/jco.2017.75.9308

• DNA methylation-based classification of central nervous system tumours

  Nature · 2018 · https://doi.org/10.1038/nature26000

• Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.08.017

• Pediatric high-grade glioma: biologically and clinically in need of new thinking

  Neuro-Oncology · 2016 · https://doi.org/10.1093/neuonc/now101

• New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.01.015

• ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

  Science Translational Medicine · 2016 · 10.1126/scitranslmed.aac8228

• Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers

  Nature Genetics · 2015 · 10.1038/ng.3368

• Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes

  Acta Neuropathologica · 2015 · 10.1007/s00401-015-1478-0

• Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge

  Nature reviews. Cancer · 2014 · https://doi.org/10.1038/nrc3655

• Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.2925

• Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma

  Nature reviews. Cancer · 2014 · 10.1038/nrc3811

• Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.2936

• The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

  Nature Genetics · 2014 · https://doi.org/10.1038/ng.2938

• Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN

  Cancer Discovery · 2013 · 10.1158/2159-8290.cd-12-0426

• Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

  Cancer Cell · 2013 · https://doi.org/10.1016/j.ccr.2013.10.006

• Paediatric and adult malignant glioma: close relatives or distant cousins?

  Nature Reviews Clinical Oncology · 2012 · 10.1038/nrclinonc.2012.87

• The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells

  Oncogene · 2012 · 10.1038/onc.2012.111

• A Role for Fibrillar Collagen Deposition and the Collagen Internalization Receptor Endo180 in Glioma Invasion

  PLoS ONE · 2010 · https://doi.org/10.1371/journal.pone.0009808

• Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease

  Journal of Clinical Oncology · 2010 · 10.1200/jco.2009.26.7252

• Common variants at 19p13 are associated with susceptibility to ovarian cancer

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.666

• Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival

  Breast Cancer Research · 2007 · 10.1186/bcr1636

• Caveolin 1 Is Overexpressed and Amplified in a Subset of Basal-like and Metaplastic Breast Carcinomas: A Morphologic, Ultrastructural, Immunohistochemical, and In situ Hybridization Analysis

  Clinical Cancer Research · 2007 · https://doi.org/10.1158/1078-0432.ccr-06-1371

• FGFR1 Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas

  Clinical Cancer Research · 2006 · https://doi.org/10.1158/1078-0432.ccr-06-1164

• EGFR amplification and lack of activating mutations in metaplastic breast carcinomas

  The Journal of Pathology · 2006 · 10.1002/path.2004

• Columnar Cell Lesions of the Breast: The Missing Link in Breast Cancer Progression?

  The American Journal of Surgical Pathology · 2005 · 10.1097/01.pas.0000157295.93914.3b

• Reelin and ApoE Receptors Cooperate to Enhance Hippocampal Synaptic Plasticity and Learning

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.m205147200

• Identification of the familial cylindromatosis tumour-suppressor gene

  Nature Genetics · 2000 · 10.1038/76006

Current projects

No projects listed.