Giuseppe Legname

Research interests

Publications

• α‐Synuclein RT‐QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies

  Annals of Clinical and Translational Neurology · 2019 · 10.1002/acn3.50897

• Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy

  Translational Neurodegeneration · 2019 · 10.1186/s40035-019-0164-x

• Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations

  Acta Neuropathologica · 2018 · 10.1007/s00401-017-1803-x

• Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

  Cell Death and Differentiation · 2013 · 10.1038/cdd.2013.180

• Protease-Sensitive Synthetic Prions

  PLoS Pathogens · 2010 · 10.1371/journal.ppat.1000736

• Continuous Quinacrine Treatment Results in the Formation of Drug-Resistant Prions

  PLoS Pathogens · 2009 · 10.1371/journal.ppat.1000673

• Design and construction of diverse mammalian prion strains

  Proceedings of the National Academy of Sciences · 2009 · 10.1073/pnas.0910350106

• Prion detection by an amyloid seeding assay

  Proceedings of the National Academy of Sciences · 2007 · 10.1073/pnas.0710152105

• Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes

  Proceedings of the National Academy of Sciences · 2006 · 10.1073/pnas.0608970103

• Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro

  Journal of Neurochemistry · 2005 · 10.1111/j.1471-4159.2005.03469.x

• Strain-specified characteristics of mouse synthetic prions

  Proceedings of the National Academy of Sciences · 2005 · 10.1073/pnas.0409079102

• Synthetic Mammalian Prions

  Science · 2004 · https://doi.org/10.1126/science.1100195

• Copper Coordination in the Full-Length, Recombinant Prion Protein

  Biochemistry · 2003 · 10.1021/bi027138+

• The influence of the src‐family kinases, Lck and Fyn, on T cell differentiation, survival and activation

  Immunological Reviews · 2003 · 10.1034/j.1600-065x.2003.00015.x

• Cytosolic Prion Protein in Neurons

  Journal of Neuroscience · 2003 · 10.1523/jneurosci.23-18-07183.2003

• A Change in the Conformation of Prions Accompanies the Emergence of a New Prion Strain

  Neuron · 2002 · 10.1016/s0896-6273(02)00726-2

• Pathway Complexity of Prion Protein Assembly into Amyloid

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.m111402200

• Prions in skeletal muscle

  Proceedings of the National Academy of Sciences · 2002 · 10.1073/pnas.052707499

• Locally Disordered Conformer of the Hamster Prion Protein: A Crucial Intermediate to PrPSc?

  Biochemistry · 2002 · 10.1021/bi026129y

• Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice

  Nature Biotechnology · 2002 · 10.1038/nbt748

• Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

  Nature · 2001 · https://doi.org/10.1038/35089090

• Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein

  Journal of Molecular Biology · 2001 · 10.1006/jmbi.2000.5183

• Folding of Prion Protein to Its Native α-Helical Conformation Is under Kinetic Control

  Journal of Biological Chemistry · 2001 · 10.1074/jbc.c100180200

• Copper-catalyzed oxidation of the recombinant SHa(29–231) prion protein

  Proceedings of the National Academy of Sciences · 2001 · 10.1073/pnas.121190898

• Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

  Immunity · 2000 · 10.1016/s1074-7613(00)80205-8

Current projects

No projects listed.