Kazuaki Chayama

Research interests

Publications

• Evidence-based clinical practice guidelines for Liver Cirrhosis 2020

  Journal of Gastroenterology · 2021 · 10.1007/s00535-021-01788-x

• Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

  Nature Genetics · 2020 · https://doi.org/10.1038/s41588-020-0640-3

• Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations

  Journal of Hepatology · 2018 · 10.1016/j.jhep.2018.01.009

• Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3547

• Individual patient data meta-analysis of controlled attenuation parameter (CAP) technology for assessing steatosis

  Journal of Hepatology · 2016 · https://doi.org/10.1016/j.jhep.2016.12.022

• Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system

  Scientific Reports · 2014 · 10.1038/srep05400

• Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection

  Hepatology · 2014 · https://doi.org/10.1002/hep.27113

• Identification of the Niemann-Pick C1–like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor

  Nature Medicine · 2012 · 10.1038/nm.2581

• Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2291

• Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population

  BMC Gastroenterology · 2012 · 10.1186/1471-230x-12-2

• Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study

  Journal of Gastroenterology · 2012 · 10.1007/s00535-012-0533-z

• Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b–infected null responders

  Hepatology · 2011 · 10.1002/hep.24724

• A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians

  Nature Genetics · 2009 · 10.1038/ng.348

• Endoscopic submucosal dissection for colorectal neoplasia: possibility of standardization

  Gastrointestinal Endoscopy · 2007 · 10.1016/j.gie.2007.02.032

• Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer

  Gastrointestinal Endoscopy · 2006 · 10.1016/j.gie.2006.03.932

• Effect of Different Intensities of Exercise on Endothelium-Dependent Vasodilation in Humans

  Circulation · 2003 · 10.1161/01.cir.0000080893.55729.28

• Endothelial Function and Oxidative Stress in Renovascular Hypertension

  New England Journal of Medicine · 2002 · 10.1056/nejmoa013591

• Clinicopathologic features and endoscopic treatment of superficially spreading colorectal neoplasms larger than 20 mm

  Gastrointestinal Endoscopy · 2001 · 10.1067/mge.2001.115729

• Interferon beta prevents recurrence of hepatocellular carcinoma after complete resection or ablation of the primary tumor—A prospective randomized study of hepatitis C virus-related liver cancer

  Hepatology · 2000 · 10.1053/jhep.2000.9409

• Effect of Interferon Therapy on Hepatocellular Carcinogenesis in Patients With Chronic Hepatitis Type C: A Long–Term Observation Study of 1,643 Patients Using Statistical Bias Correction With Proportional Hazard Analysis

  Hepatology · 1999 · 10.1002/hep.510290439

• Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy

  Hepatology · 1998 · 10.1002/hep.510270634

• Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis: a prospective observation of 2215 patients

  Journal of Hepatology · 1998 · 10.1016/s0168-8278(98)80339-5

• The long term efficacy of glycyrrhizin in chronic hepatitis C patients

  Cancer · 1997 · 10.1002/(sici)1097-0142(19970415)79:8<1494::aid-cncr8>3.0.co;2-b

• A proposed system for the nomenclature of hepatitis C viral genotypes

  Hepatology · 1994 · 10.1002/hep.1840190538

• A multivariate analysis of risk factors for hepatocellular carcinogenesis: A prospective observation of 795 patients with viral and alcoholic cirrhosis

  Hepatology · 1993 · 10.1002/hep.1840180109

Current projects

No projects listed.