Josef Penninger

Research interests

Publications

• Autophagy in major human diseases

  The EMBO Journal · 2021 · https://doi.org/10.15252/embj.2021108863

• Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

  Intensive Care Medicine · 2020 · https://doi.org/10.1007/s00134-020-05985-9

• Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

  Cell · 2020 · 10.1016/j.cell.2020.04.004

• Human blood vessel organoids as a model of diabetic vasculopathy

  Nature · 2019 · https://doi.org/10.1038/s41586-018-0858-8

• Molecular definitions of autophagy and related processes

  The EMBO Journal · 2017 · https://doi.org/10.15252/embj.201796697

• Autophagy in malignant transformation and cancer progression

  The EMBO Journal · 2015 · https://doi.org/10.15252/embj.201490784

• Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

  Cell Death and Differentiation · 2014 · 10.1038/cdd.2014.137

• Cerebral organoids model human brain development and microcephaly

  Nature · 2013 · https://doi.org/10.1038/nature12517

• ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

  Nature · 2012 · 10.1038/nature11228

• Evidence for osteocyte regulation of bone homeostasis through RANKL expression

  Nature Medicine · 2011 · 10.1038/nm.2452

• Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

  Nature · 2010 · 10.1038/nature09387

• Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

  Cell · 2008 · 10.1016/j.cell.2008.02.043

• Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN

  Nature · 2006 · 10.1038/nature04925

• RANKL–RANK signaling in osteoclastogenesis and bone disease

  Trends in Molecular Medicine · 2005 · 10.1016/j.molmed.2005.11.007

• A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

  Nature Medicine · 2005 · https://doi.org/10.1038/nm1267

• Angiotensin-converting enzyme 2 protects from severe acute lung failure

  Nature · 2005 · 10.1038/nature03712

• Mitogen-activated protein kinases in apoptosis regulation

  Oncogene · 2004 · 10.1038/sj.onc.1207556

• Angiotensin-converting enzyme 2 is an essential regulator of heart function

  Nature · 2002 · 10.1038/nature00786

• Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

  Nature · 2001 · 10.1038/35069004

• Molecular characterization of mitochondrial apoptosis-inducing factor

  Nature · 1999 · https://doi.org/10.1038/17135

• Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

  Nature · 1999 · 10.1038/46303

• OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

  Nature · 1999 · https://doi.org/10.1038/16852

• TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

  Genes & Development · 1999 · 10.1101/gad.13.8.1015

• Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

  Cell · 1998 · 10.1016/s0092-8674(00)81477-4

• Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

  Cell · 1998 · 10.1016/s0092-8674(00)81733-x

• Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

  Cell · 1998 · 10.1016/s0092-8674(00)81780-8

• Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4

  Science · 1995 · 10.1126/science.270.5238.985

Current projects

No projects listed.